publication . Article . 2016

Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection

Eu Suk Kim; Pyoeng Gyun Choe; Wan Beom Park; Hong Sang Oh; Eun Jung Kim; Eun Young Nam; Sun Hee Na; Moonsuk Kim; Kyoung-Ho Song; Ji Hwan Bang; ...
Open Access English
  • Published: 05 Oct 2016 Journal: Journal of Korean Medical Science, volume 31, issue 11, pages 1,717-1,725 (issn: 1011-8934, eissn: 1598-6357, Copyright policy)
  • Publisher: The Korean Academy of Medical Sciences
Clinical progression over time and cytokine profiles have not been well defined in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection. We included 17 patients with laboratory-confirmed MERS-CoV during the 2015 outbreak in Korea. Clinical and laboratory parameters were collected prospectively. Serum cytokine and chemokine levels in serial serum samples were measured using enzyme-linked immunosorbent assay. All patients presented with fever. The median time to defervescence was 18 days. Nine patients required oxygen supplementation and classified into severe group. In the severe group, chest infiltrates suddenly began to worsen around ...
Persistent Identifiers
free text keywords: Original Article, Infectious Diseases, Microbiology & Parasitology, MERS, Coronavirus, Clinical Progression, Cytokine, Chemokine, IFN-α, IL-6, CXCL-10, Severity, General Medicine, Immunology, Creatinine, chemistry.chemical_compound, chemistry, Outbreak, Coronavirus, medicine.disease_cause, medicine, Middle East respiratory syndrome coronavirus, Internal medicine, medicine.medical_specialty, Cytokine, medicine.medical_treatment, Prothrombin time, medicine.diagnostic_test, Interleukin 6, biology.protein, biology, Severity of illness, business.industry, business, Gastroenterology
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26 references, page 1 of 2

Zaki, AM, van Boheemen, S, Bestebroer, TM, Osterhaus, AD, Fouchier, RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012; 367: 1814-1820 [OpenAIRE] [PubMed]

Middle East respiratory syndrome coronavirus (MERS-CoV) - Saudi Arabia: disease outbreak news, 14 April 2016 [Internet].

Lee, J. Better understanding on MERS corona virus outbreak in Korea. J Korean Med Sci. 2015; 30: 835-836 [OpenAIRE] [PubMed]

Middle East respiratory syndrome coronavirus outbreak in the Republic of Korea, 2015. Osong Public Health Res Perspect. 2015; 6: 269-278 [OpenAIRE] [PubMed]

Oh, MD, Choe, PG, Oh, HS, Park, WB, Lee, SM, Park, J, Lee, SK, Song, JS, Kim, NJ. Middle East respiratory syndrome coronavirus superspreading event involving 81 persons, Korea 2015. J Korean Med Sci. 2015; 30: 1701-1705 [OpenAIRE] [PubMed]

Summary and risk assessment of current situation in Republic of Korea and China: MERS-CoV risk assessment, 19 June 2015 [Internet].

de Jong, MD, Simmons, CP, Thanh, TT, Hien, VM, Smith, GJ, Chau, TN, Hoang, DM, Chau, NV, Khanh, TH, Dong, VC. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med. 2006; 12: 1203-1207 [OpenAIRE] [PubMed]

Wang, Z, Zhang, A, Wan, Y, Liu, X, Qiu, C, Xi, X, Ren, Y, Wang, J, Dong, Y, Bao, M. Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection. Proc Natl Acad Sci USA. 2014; 111: 769-774 [OpenAIRE] [PubMed]

Wong, CK, Lam, CW, Wu, AK, Ip, WK, Lee, NL, Chan, IH, Lit, LC, Hui, DS, Chan, MH, Chung, SS. Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clin Exp Immunol. 2004; 136: 95-103 [OpenAIRE] [PubMed]

Oh, MD, Park, WB, Choe, PG, Choi, SJ, Kim, JI, Chae, J, Park, SS, Kim, EC, Oh, HS, Kim, EJ. Viral load kinetics of MERS coronavirus infection. N Engl J Med. 2016

Park, WB, Perera, RA, Choe, PG, Lau, EH, Choi, SJ, Chun, JY, Oh, HS, Song, KH, Bang, JH, Kim, ES. Kinetics of serologic responses to MERS coronavirus infection in humans, South Korea. Emerg Infect Dis. 2015; 21: 2186-2189 [OpenAIRE] [PubMed]

Laboratory testing for Middle East respiratory syndrome coronavirus: interim guidance [Internet].

Wang, WK, Chen, SY, Liu, IJ, Kao, CL, Chen, HL, Chiang, BL, Wang, JT, Sheng, WH, Hsueh, PR, Yang, CF. Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome. Clin Infect Dis. 2004; 39: 1071-1075 [OpenAIRE] [PubMed]

Assiri, A, Al-Tawfiq, JA, Al-Rabeeah, AA, Al-Rabiah, FA, Al-Hajjar, S, Al-Barrak, A, Flemban, H, Al-Nassir, WN, Balkhy, HH, Al-Hakeem, RF. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis. 2013; 13: 752-761 [OpenAIRE] [PubMed]

Assiri, A, McGeer, A, Perl, TM, Price, CS, Al Rabeeah, AA, Cummings, DA, Alabdullatif, ZN, Assad, M, Almulhim, A, Makhdoom, H. Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med. 2013; 369: 407-416 [OpenAIRE] [PubMed]

26 references, page 1 of 2
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