publication . Article . 2016

Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection

Eu Suk Kim; Pyoeng Gyun Choe; Wan Beom Park; Hong Sang Oh; Eun Jung Kim; Eun Young Nam; Sun Hee Na; Moonsuk Kim; Kyoung-Ho Song; Ji Hwan Bang; ...
Open Access English
  • Published: 05 Oct 2016 Journal: Journal of Korean Medical Science, volume 31, issue 11, pages 1,717-1,725 (issn: 1011-8934, eissn: 1598-6357, Copyright policy)
  • Publisher: The Korean Academy of Medical Sciences
Abstract
Clinical progression over time and cytokine profiles have not been well defined in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection. We included 17 patients with laboratory-confirmed MERS-CoV during the 2015 outbreak in Korea. Clinical and laboratory parameters were collected prospectively. Serum cytokine and chemokine levels in serial serum samples were measured using enzyme-linked immunosorbent assay. All patients presented with fever. The median time to defervescence was 18 days. Nine patients required oxygen supplementation and classified into severe group. In the severe group, chest infiltrates suddenly began to worsen around ...
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free text keywords: Original Article, Infectious Diseases, Microbiology & Parasitology, MERS, Coronavirus, Clinical Progression, Cytokine, Chemokine, IFN-α, IL-6, CXCL-10, Severity, General Medicine, Immunology, Creatinine, chemistry.chemical_compound, chemistry, Outbreak, Coronavirus, medicine.disease_cause, medicine, Middle East respiratory syndrome coronavirus, Internal medicine, medicine.medical_specialty, Cytokine, medicine.medical_treatment, Prothrombin time, medicine.diagnostic_test, Interleukin 6, biology.protein, biology, Severity of illness, business.industry, business, Gastroenterology
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