publication . Article . 2017

MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015

Pyoeng Gyun Choe; Ranawaka A.P.M. Perera; Wan Beom Park; Kyoung-Ho Song; Ji Hwan Bang; Eu Suk Kim; Hong Bin Kim; Long Wei Ronald Ko; Sang Won Park; Nam Joong Kim; ...
Open Access
  • Published: 01 Jan 2017 Journal: Emerging Infectious Diseases, volume 23, issue 7, pages 1,079-1,084 (issn: 1080-6040, eissn: 1080-6059, Copyright policy)
  • Publisher: Centers for Disease Control and Prevention (CDC)
Abstract
We investigated the kinetics of the Middle East respiratory syndrome coronavirus (MERS-CoV) neutralizing and spike protein antibody titers over the course of 1 year in 11 patients who were confirmed by reverse transcription PCR to have been infected during the outbreak in South Korea in 2015. Robust antibody responses were detected in all survivors who had severe disease; responses remained detectable, albeit with some waning, for <1 year. The duration of viral RNA detection (but not viral load) in sputum significantly correlated with the antibody response magnitude. The MERS S1 ELISA antibody titers correlated well with the neutralizing antibody response. Antib...
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free text keywords: Research, MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015, Middle East respiratory syndrome coronavirus, MERS, coronavirus, MERS-CoV, antibody, serology, kinetics, human, South Korea, viruses, zoonoses, neutralization, China, Antibody, biology.protein, biology, Virology, Immunology, Serology, Neutralizing antibody, Coronavirus, medicine.disease_cause, medicine, Viral load, Middle East respiratory syndrome coronavirus, Antibody titer, Sputum, medicine.symptom, business.industry, business
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