publication . Article . 2004

Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome

Peter K.C. Cheng; Derek A. Wong; Louis K.L. Tong; Sin-Ming Ip; Angus C T Lo; C.S. Lau; Eugene Y.H. Yeung; Wilina Lim;
Open Access English
  • Published: 26 May 2004 Journal: Lancet (London, England), volume 363, issue 9,422, pages 1,699-1,700 (issn: 0140-6736, eissn: 1474-547X, Copyright policy)
  • Publisher: Elsevier Ltd.
Summary Severe acute respiratory syndrome (SARS) is thought to be caused by a novel coronavirus, SARS-associated coronavirus. We studied viral shedding of SARS coronavirus to improve diagnosis and infection control. Reverse-transcriptase PCR was done on 2134 specimens of different types. 355 (45%) specimens of nasopharyngeal aspirates and 150 (28%) of faeces were positive for SARS coronavirus RNA. Positive rates peaked at 6–11 days after onset of illness for nasopharyngeal aspirates (87 of 149 [58%], to 37 of 62 [60%]), and 9–14 days for faeces (15 of 22 [68%], to 26 of 37 [70%]). Overall, peak viral loads were reached at 12–14 days of illness when patients were...
Medical Subject Headings: viruses
free text keywords: Article, Nidovirales, biology.organism_classification, biology, Respiratory disease, medicine.disease, medicine, Viral shedding, Coronaviridae, Virology, Immunology, Viral disease, Viral load, Coronavirus, medicine.disease_cause, Virus, business.industry, business

Severe acute respiratory syndrome (SARS): multi-country outbreak—update 34.

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