publication . Review . Article . 2014

Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development

Madhu Khanna; Sachin Sharma; Binod Kumar; Roopali Rajput;
Open Access English
  • Published: 01 Jan 2014 Journal: BioMed Research International (issn: 2314-6133, Copyright policy)
  • Publisher: Hindawi Publishing Corporation
<jats:p>Influenza virus surface glycoprotein hemagglutinin (HA) is an excellent and chief target that<jats:italic>elicits</jats:italic>neutralizing antibodies during vaccination or natural infection. Its HA2 subunit (stem domain) is most conserved as compared to HA1 subunit (globular head domain). Current influenza vaccine relies on globular head domain that provides protection only against the homologous vaccine strains, rarely provides cross-protection against divergent strains, and needs to be updated annually. There is an urge for a truly universal vaccine that provides broad cross-protection against different subtype influenza A viruses along with influenza...
Persistent Identifiers
free text keywords: Article Subject, Review Article, General Biochemistry, Genetics and Molecular Biology, General Immunology and Microbiology, General Medicine, Virus, Antigenic drift, Hemagglutinin (influenza), biology.protein, biology, Influenza vaccine, Virology, DNA vaccination, Microbiology, Epitope, Vaccination, H5N1 genetic structure, lcsh:Medicine, lcsh:R
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