publication . Review . Article . 2014

Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development

Madhu Khanna; Sachin Sharma; Binod Kumar; Roopali Rajput;
Open Access English
  • Published: 01 Jan 2014 Journal: BioMed Research International (issn: 2314-6133, Copyright policy)
  • Publisher: Hindawi Publishing Corporation
Abstract
<jats:p>Influenza virus surface glycoprotein hemagglutinin (HA) is an excellent and chief target that<jats:italic>elicits</jats:italic>neutralizing antibodies during vaccination or natural infection. Its HA2 subunit (stem domain) is most conserved as compared to HA1 subunit (globular head domain). Current influenza vaccine relies on globular head domain that provides protection only against the homologous vaccine strains, rarely provides cross-protection against divergent strains, and needs to be updated annually. There is an urge for a truly universal vaccine that provides broad cross-protection against different subtype influenza A viruses along with influenza...
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Subjects
free text keywords: Article Subject, Review Article, General Biochemistry, Genetics and Molecular Biology, General Immunology and Microbiology, General Medicine, Virus, Antigenic drift, Hemagglutinin (influenza), biology.protein, biology, Influenza vaccine, Virology, DNA vaccination, Microbiology, Epitope, Vaccination, H5N1 genetic structure, lcsh:Medicine, lcsh:R
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41 references, page 1 of 3

Tong, S, Zhu, X, Li, Y, Shi, M, Zhang, J, Bourgeois, M. New world bats harbor diverse influenza A viruses. PLoS Pathogens . 2013; 9 (10): 1-12

Zhu, X, Yu, W, McBride, R. Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities. Proceedings of the National Academy of Sciences of the United States of America . 2013; 110 (4): 1458-1463 [OpenAIRE] [PubMed] []

Taubenberger, JK, Morens, DM. 1918 Influenza: the mother of all pandemics. Emerging Infectious Diseases . 2006; 12 (1): 15-22 [OpenAIRE] [PubMed] []

Guan, Y, Vijaykrishna, D, Bahl, J, Zhu, H, Wang, J, Smith, GJD. The emergence of pandemic influenza viruses. Protein and Cell . 2010; 1 (1): 9-13 [OpenAIRE] [PubMed] []

Khanna, M, Saxena, L, Gupta, A, Kumar, B, Rajput, R. Influenza pandemics of 1918 and 2009: a comparative account. Future Virology . 2013; 8 (4): 335-342 []

Goldsmith, C. It’s just the flu. Influenza: The Next Pande Mic? . 2007

Ekiert, DC, Bhabha, G, Elsliger, M-A. Antibody recognition of a highly conserved influenza virus epitope. Science . 2009; 324 (5924): 246-251 [OpenAIRE] [PubMed] []

Belser, JA, Lu, X, Maines, TR. Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: enhanced virulence of eurasian H7N7 viruses isolated from humans. Journal of Virology . 2007; 81 (20): 11139-11147 [OpenAIRE] [PubMed] []

Lin, YP, Shaw, M, Gregory, V. Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates. Proceedings of the National Academy of Sciences of the United States of America . 2000; 97 (17): 9654-9658 [OpenAIRE] [PubMed] []

Claas, ECJ, Osterhaus, ADME, Van Beek, R. Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet . 1998; 351 (9101): 472-477 [OpenAIRE] [PubMed] []

Beigel, JH, Farrar, J, Han, AM. Avian influenza A (H5N1) infection in humans. The New England Journal of Medicine . 2005; 353 (13): 1374-1385 [PubMed] []

Ge, Y, Wu, B, Qi, X, Zhao, K, Guo, X. Rapid and sensitive detection of novel avian-origin influenza A, (H7N9) virus by reverse transcription loop- mediated isothermal amplification combined with a lateral- flow device. PLoS ONE . 2013; 8 (8, article e69941)

Zhirnov, OP, Ikizler, MR, Wright, PF. Cleavage of influenza A virus hemagglutinin in human respiratory epithelium is cell associated and sensitive to exogenous antiproteases. Journal of Virology . 2002; 76 (17): 8682-8689 [OpenAIRE] [PubMed] []

Both, GW, Sleigh, MJ, Cox, NJ, Kendal, AP. Antigenic drift in influenza virus H3 hemagglutinin from 1968 to 1980: multiple evolutionary pathways and sequential amino acid changes at key antigenic sites. Journal of Virology . 1983; 48 (1): 52-60 [OpenAIRE] [PubMed] []

Gocník, M, Fislová, T, Mucha, V. Antibodies induced by the HA2 glycopolypeptide of influenza haemagglutinin improve recovery from influenza A virus infection. Journal of General Virology . 2008; 89 (4): 958-967 [PubMed] []

41 references, page 1 of 3
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