publication . Article . 2002

Prospects for cationic polymers in gene and oligonucleotide therapy against cancer

Thomas Merdan; Jindrich Kopecek; Thomas Kissel;
  • Published: 08 Oct 2002 Journal: Advanced Drug Delivery Reviews, volume 54, pages 715-758 (issn: 0169-409X, Copyright policy)
  • Publisher: Elsevier BV
Gene and antisense/ribozyme therapy possesses tremendous potential for the successful treatment of genetically based diseases, such as cancer. Several cancer gene therapy strategies have already been realized in vitro, as well as in vivo. A few have even reached the stage of clinical trials, most of them phase I, while some antisense strategies have advanced to phase II and III studies. Despite this progress, a major problem in exploiting the full potential of cancer gene therapy is the lack of a safe and efficient delivery system for nucleic acids. As viral vectors possess toxicity and immunogenicity, non-viral strategies are becoming more and more attractive. ...
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free text keywords: Pharmaceutical Science, Biochemistry, Sense (molecular biology), Computational biology, Gene, Cancer, medicine.disease, medicine, Ribozyme, biology.protein, biology, Viral vector, Transfection, Oligonucleotide, Genetic enhancement
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