publication . Article . 2020

Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology

Schrezenmeier, Eva; Dörner, Thomas;
Open Access
  • Published: 07 Feb 2020
  • Publisher: Springer Science and Business Media LLC
Abstract
Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and chloroquine in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases, insights into the mechanism of action of these drugs are still emerging. Hydroxychloroquine and chloroquine are weak bases and have a characteristic 'deep' volume of distribution and a half-life of around 50 days. These drugs interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in inhibition of cytokine production and modulation of certain ...
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free text keywords: Rheumatology, Adverse effect, Pharmacology, Arthritis, medicine.disease, medicine, Hydroxychloroquine, medicine.drug, Mechanism of action, medicine.symptom, Chloroquine, business.industry, business, Rheumatoid arthritis, Blood drug, Drug, media_common.quotation_subject, media_common
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