publication . Article . 2021

Regulation of the acetylcholine/α7nAChR anti-inflammatory pathway in COVID-19 patients

Courties, Alice; Boussier, Jeremy; Hadjadj, Jérôme; Yatim, Nader; Barnabei, Laura; Péré, Hélène; Veyer, David; Kernéis, Solen; Carlier, Nicolas; Pène, Frédéric; ...
Open Access English
  • Published: 04 Jun 2021
  • Publisher: HAL CCSD
  • Country: France
Abstract
International audience; The cholinergic system has been proposed as a potential regulator of COVID-19-induced hypercytokinemia. We investigated whole-blood expression of cholinergic system members and correlated it with COVID-19 severity. Patients with confirmed SARS-CoV-2 infection and healthy aged-matched controls were included in this non-interventional study. A whole blood sample was drawn between 9-11 days after symptoms onset, and peripheral leukocyte phenotyping, cytokines measurement, RNA expression and plasma viral load were determined. Additionally, whole-blood expression of native alpha-7 nicotinic subunit and its negative dominant duplicate (CHRFAM7A...
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free text keywords: [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Medicine, R, Science, Q, Article, Acute inflammation, Viral infection
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