publication . Article . Other literature type . 2011

Unconventional Use of LC3 by Coronaviruses through the Alleged Subversion of the ERAD Tuning Pathway

Reggiori, F.; de Haan, C.A.M.; Molinari, M; Strategic Infection Biology; Dep Infectieziekten Immunologie;
Open Access
  • Published: 01 Sep 2011
Abstract
Pathogens of bacterial and viral origin hijack pathways operating in eukaryotic cells in many ways in order to gain access into the host, to establish themselves and to eventually produce their progeny. The detailed molecular characterization of the subversion mechanisms devised by pathogens to infect host cells is crucial to generate targets for therapeutic intervention. Here we review recent data indicating that coronaviruses probably co-opt membranous carriers derived from the endoplasmic reticulum, which contain proteins that regulate disposal of misfolded polypeptides, for their replication. In addition, we also present models describing potential mechanisms that coronaviruses could employ for this hijacking.
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Fields of Science and Technology classification (FOS)
03 medical and health sciences, 0303 health sciences, 030302 biochemistry & molecular biology, 030304 developmental biology
Subjects
Medical Subject Headings: viruses
free text keywords: coronaviruses, nidoviruses, double-membrane vesicles, Mhv, SARS-coronavirus, autophagy, EDEMosomes, Edem1, Os-9, Erad, ER quality control, Acute-Respiratory-Syndrome, Feline Infectious Peritonitis, Endoplasmic-Reticulum Stress, Mouse Hepatitis-Virus, Autophagosome Formation, Replication Complex, Spike Protein, Molecular Characterization, Mammalian Autophagy, Review, Virology, Infectious Diseases, Coronaviridae, biology.organism_classification, biology, Membrane protein, Endoplasmic-reticulum-associated protein degradation, Subversion, Viral replication, Severe acute respiratory syndrome coronavirus, Endoplasmic reticulum, Spike Protein, Cell biology, lcsh:Microbiology, lcsh:QR1-502
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