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Pharmaceutics
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Pharmaceutics
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Pharmaceutics
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Functionalizing Ferritin Nanoparticles for Vaccine Development

Authors: Margarida Q. Rodrigues; Paula M. Alves; António Roldão;

Functionalizing Ferritin Nanoparticles for Vaccine Development

Abstract

In the last decade, the interest in ferritin-based vaccines has been increasing due to their safety and immunogenicity. Candidates against a wide range of pathogens are now on Phase I clinical trials namely for influenza, Epstein-Barr, and SARS-CoV-2 viruses. Manufacturing challenges related to particle heterogeneity, improper folding of fused antigens, and antigen interference with intersubunit interactions still need to be overcome. In addition, protocols need to be standardized so that the production bioprocess becomes reproducible, allowing ferritin-based therapeutics to become readily available. In this review, the building blocks that enable the formulation of ferritin-based vaccines at an experimental stage, including design, production, and purification are presented. Novel bioengineering strategies of functionalizing ferritin nanoparticles based on modular assembly, allowing the challenges associated with genetic fusion to be circumvented, are discussed. Distinct up/down-stream approaches to produce ferritin-based vaccines and their impact on production yield and vaccine efficacy are compared. Finally, ferritin nanoparticles currently used in vaccine development and clinical trials are summarized.

Subjects by Vocabulary

Microsoft Academic Graph classification: 2019-20 coronavirus outbreak biology Coronavirus disease 2019 (COVID-19) Recombinant expression Computer science Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Immunogenicity Computational biology Vaccine efficacy Ferritin biology.protein Bioprocess

Keywords

ferritin nanoparticles, Pharmaceutical Science, Review, recombinant expression, vaccines, genetic fusion, RS1-441, Pharmacy and materia medica, modular assembly, surface decoration

97 references, page 1 of 10

1. Karch, C.P.; Burkhard, P. Vaccine technologies: From whole organisms to rationally designed protein assemblies. Biochem. Pharmacol. 2016, 120, 1-14. [CrossRef] [PubMed] [OpenAIRE]

Rehm, B.H. Bioengineering towards self-assembly of particulate vaccines. Curr. Opin. Biotechnol. 2017, 48, 42-53. [CrossRef] Parmiani, G.; Castelli, C.; Dalerba, P.; Mortarini, R.; Rivoltini, L.; Marincola, F.M.; Anichini, A. Cancer Immunotherapy With Peptide-Based Vaccines: What Have We Achieved? Where Are We Going? J. Natl. Cancer Inst. 2002, 94, 805-818. [CrossRef] [PubMed]

Yeste, A.; Nadeau, M.; Burns, E.J.; Weiner, H.L.; Quintana, F.J. Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 2012, 109, 11270-11275. [CrossRef] [OpenAIRE]

5. Hunter, Z.; McCarthy, D.P.; Yap, W.T.; Harp, C.T.; Getts, D.R.; Shea, L.D.; Miller, S.D. A Biodegradable Nanoparticle Platform for the Induction of Antigen-Specific Immune Tolerance for Treatment of Autoimmune Disease. ACS Nano 2014, 8, 2148-2160. [CrossRef] [OpenAIRE]

6. Smith, D.M.; Simon, J.K.; Jr, J.R.B. Applications of nanotechnology for immunology. Nat. Rev. Immunol. 2013, 13, 592-605. [CrossRef] [OpenAIRE]

7. Lung, P.; Yang, J.; Li, Q. Nanoparticle formulated vaccines: Opportunities and challenges. Nanoscale 2020, 12, 5746-5763. [CrossRef]

8. Foged, C.; Brodin, B.; Frokjaer, S.; Sundblad, A. Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model. Int. J. Pharm. 2005, 298, 315-322. [CrossRef] [PubMed]

9. Tokatlian, T.; Read, B.J.; Jones, C.A.; Kulp, D.W.; Menis, S.; Chang, J.Y.H.; Steichen, J.M.; Kumari, S.; Allen, J.D.; Dane, E.L.; et al. Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers. Science 2018, 363, 649-654. [CrossRef]

10. Hoshyar, N.; Gray, S.; Han, H.; Bao, G. The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction. Nanomedicine 2016, 11, 673-692. [CrossRef]

11. Lee, E.J.; Lee, N.K.; Kim, I.-S. Bioengineered protein-based nanocage for drug delivery. Adv. Drug Deliv. Rev. 2016, 106, 157-171. [CrossRef]

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    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
39
Top 1%
Average
Top 1%
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