publication . Article . 2020

Is There a Link between Bisphenol A (BPA), a Key Endocrine Disruptor, and the Risk for SARS-CoV-2 Infection and Severe COVID-19?

Aeman Zahra; Cristina Sisu; Elisabete Silva; Sophie-Christine de Aguiar Greca; Harpal S. Randeva; Kamaljit Chatha; Ioannis Kyrou; Emmanouil Karteris;
Open Access
  • Published: 14 Oct 2020 Journal: Journal of Clinical Medicine, volume 9, page 3,296 (eissn: 2077-0383, Copyright policy)
  • Publisher: MDPI AG
  • Country: United Kingdom
© 2020 by the authors. Infection by the severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) is the causative agent of a new disease (COVID-19). The risk of severe COVID-19 is increased by certain underlying comorbidities, including asthma, cancer, cardiovascular disease, hypertension, diabetes, and obesity. Notably, exposure to hormonally active chemicals, so called, endocrine disrupting chemicals (EDCs) can promote such cardio-metabolic diseases, endocrine-related cancers, and immune system dysregulation and, thus, may also be linked to higher risk of severe COVID-19. Bisphenol A (BPA) is among the most common EDCs and exerts its effects via receptors which are widely distributed in human tissues, including nuclear estrogen receptors (ERα and ERβ), membrane-bound estrogen receptor GPR30 and human nuclear receptor estrogen-related receptor gamma. As such, this paper focuses on the potential role of BPA in promoting comorbidities associated with severe COVID-19, as well as on potential BPA-induced effects on key SARS-CoV-2 infection mediators, such as angiotensin-converting enzyme 2 (ACE2), and transmembrane serine protease 2 (TMPRSS2). Interestingly, GPR30 appears to exhibit greater co-localisation with TMPRSS2 in key tissues like lung, and prostate, suggesting that BPA exposure may impact on the local expression of these SARS-CoV-2 infection mediators. Overall, the potential role of BPA on the risk and severity of COVID-19 merits further investigation. Isambard Kingdom Brunel Research Scholarship Isambard Kingdom Brunel Research Scholarship
Persistent Identifiers
Fields of Science and Technology classification (FOS)
03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, 0303 health sciences, 030304 developmental biology
Sustainable Development Goals (SDG)
2. Zero hunger
free text keywords: General Engineering, SARS-CoV-2, COVID-19, BPA, estrogen receptors, ACE2, TMPRSS2, endocrine disruptors, SARS-CoV-2, COVID-19, BPA, oestrogen receptors, ACE2, TMPRSS2, Review, endocrine disruptors, TMPRSS2, Endocrine disruptor, GPER, Nuclear receptor, Disease, Immunology, Estrogen receptor, Medicine, business.industry, business, Immune system, Receptor, lcsh:Medicine, lcsh:R
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