publication . Article . 2018

Innate Immune Responses and Viral-Induced Neurologic Disease

Yuting Cheng; Dominic D Skinner; Thomas E. Lane;
Open Access English
  • Published: 20 Dec 2018 Journal: Journal of Clinical Medicine, volume 8, issue 1 (eissn: 2077-0383, Copyright policy)
  • Publisher: MDPI
Abstract
<jats:p>Multiple sclerosis (MS) is a disease of the central nervous system (CNS) characterized by chronic neuroinflammation, axonal damage, and demyelination. Cellular components of the adaptive immune response are viewed as important in initiating formation of demyelinating lesions in MS patients. This notion is supported by preclinical animal models, genome-wide association studies (GWAS), as well as approved disease modifying therapies (DMTs) that suppress clinical relapse and are designed to impede infiltration of activated lymphocytes into the CNS. Nonetheless, emerging evidence demonstrates that the innate immune response e.g., neutrophils can amplify whit...
Persistent Identifiers
Subjects
free text keywords: Review, virus, innate immunity, neutrophils, demyelination, remyelination, lcsh:Medicine, lcsh:R, Immunology, Innate immune system, Disease, Remyelination, medicine.anatomical_structure, medicine, Central nervous system, Neuroinflammation, Acquired immune system, Demyelinating disease, medicine.disease, business.industry, business, Multiple sclerosis
Funded by
NIH| Chemokines and Viral-Induced Neurologic Disease
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2R01NS041249-16A1
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Communities
COVID-19
113 references, page 1 of 8

Steinman, L.. Immunology of Relapse and Remission in Multiple Sclerosis. Annu. Rev. Immunol.. 2014; 32: 257-281 [OpenAIRE] [PubMed] [DOI]

Lassmann, H., Bruck, W., Lucchinetti, C.F.. The immunopathology of multiple sclerosis: An overview. Brain Pathol.. 2007; 17: 210-218 [OpenAIRE] [PubMed] [DOI]

Neumann, H., Medana, I.M., Bauer, J., Lassmann, H.. Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases. Trends Neurosci.. 2002; 25: 313-319 [PubMed] [DOI]

Steinman, L.. Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system. Cell. 1996; 85: 299-302 [OpenAIRE] [PubMed] [DOI]

Greenfield, A.L., Hauser, S.L.. B-cell Therapy for Multiple Sclerosis: Entering an era. Ann. Neurol.. 2018; 83: 13-26 [OpenAIRE] [PubMed] [DOI]

Falcao, A.M., van Bruggen, D., Marques, S., Meijer, M., Jakel, S., Agirre, E., Samudyata, null, Floriddia, E.M., Vanichkina, D.P., Ffrench-Constant, C.. Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis. Nat. Med.. 2018; 24: 1837-1844 [OpenAIRE] [PubMed] [DOI]

Chang, A., Nishiyama, A., Peterson, J., Prineas, J., Trapp, B.D.. NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. J. Neurosci.. 2000; 20: 6404-6412 [OpenAIRE] [PubMed] [DOI]

Prineas, J.W., Kwon, E.E., Goldenberg, P.Z., Ilyas, A.A., Quarles, R.H., Benjamins, J.A., Sprinkle, T.J.. Multiple sclerosis. Oligodendrocyte proliferation and differentiation in fresh lesions. Lab. Investig.. 1989; 61: 489-503 [PubMed]

Lucchinetti, C., Bruck, W., Parisi, J., Scheithauer, B., Rodriguez, M., Lassmann, H.. A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases. Brain. 1999; 122: 2279-2295 [OpenAIRE] [PubMed] [DOI]

Roy, N.S., Wang, S., Harrison-Restelli, C., Benraiss, A., Fraser, R.A., Gravel, M., Braun, P.E., Goldman, S.A.. Identification, isolation, and promoter-defined separation of mitotic oligodendrocyte progenitor cells from the adult human subcortical white matter. J. Neurosci.. 1999; 19: 9986-9995 [OpenAIRE] [PubMed] [DOI]

Lassmann, H.. Comparative neuropathology of chronic experimental allergic encephalomyelitis and multiple sclerosis. Schriftenr. Neurol.. 1983; 25: 1-135 [PubMed]

Schlesinger, H.. Zur Frage der akuten multiplen Sklerose und der encephalomyelitis disseminata im Kindesalter. Arb. Neurol. Inst.. 1909; 17: 410-432

Halfpenny, C., Benn, T., Scolding, N.. Cell transplantation, myelin repair, and multiple sclerosis. Lancet Neurol.. 2002; 1: 31-40 [OpenAIRE] [PubMed] [DOI]

Oksenberg, J.R., Begovich, A.B., Erlich, H.A., Steinman, L.. Genetic factors in multiple sclerosis. Jama. 1993; 270: 2362-2369 [OpenAIRE] [PubMed] [DOI]

Poser, C.M.. The epidemiology of multiple sclerosis: A general overview. Ann. Neurol.. 1994; 36 (Suppl. 2): S180-S193 [OpenAIRE] [PubMed] [DOI]

113 references, page 1 of 8
Related research
Abstract
<jats:p>Multiple sclerosis (MS) is a disease of the central nervous system (CNS) characterized by chronic neuroinflammation, axonal damage, and demyelination. Cellular components of the adaptive immune response are viewed as important in initiating formation of demyelinating lesions in MS patients. This notion is supported by preclinical animal models, genome-wide association studies (GWAS), as well as approved disease modifying therapies (DMTs) that suppress clinical relapse and are designed to impede infiltration of activated lymphocytes into the CNS. Nonetheless, emerging evidence demonstrates that the innate immune response e.g., neutrophils can amplify whit...
Persistent Identifiers
Subjects
free text keywords: Review, virus, innate immunity, neutrophils, demyelination, remyelination, lcsh:Medicine, lcsh:R, Immunology, Innate immune system, Disease, Remyelination, medicine.anatomical_structure, medicine, Central nervous system, Neuroinflammation, Acquired immune system, Demyelinating disease, medicine.disease, business.industry, business, Multiple sclerosis
Funded by
NIH| Chemokines and Viral-Induced Neurologic Disease
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2R01NS041249-16A1
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Communities
COVID-19
113 references, page 1 of 8

Steinman, L.. Immunology of Relapse and Remission in Multiple Sclerosis. Annu. Rev. Immunol.. 2014; 32: 257-281 [OpenAIRE] [PubMed] [DOI]

Lassmann, H., Bruck, W., Lucchinetti, C.F.. The immunopathology of multiple sclerosis: An overview. Brain Pathol.. 2007; 17: 210-218 [OpenAIRE] [PubMed] [DOI]

Neumann, H., Medana, I.M., Bauer, J., Lassmann, H.. Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases. Trends Neurosci.. 2002; 25: 313-319 [PubMed] [DOI]

Steinman, L.. Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system. Cell. 1996; 85: 299-302 [OpenAIRE] [PubMed] [DOI]

Greenfield, A.L., Hauser, S.L.. B-cell Therapy for Multiple Sclerosis: Entering an era. Ann. Neurol.. 2018; 83: 13-26 [OpenAIRE] [PubMed] [DOI]

Falcao, A.M., van Bruggen, D., Marques, S., Meijer, M., Jakel, S., Agirre, E., Samudyata, null, Floriddia, E.M., Vanichkina, D.P., Ffrench-Constant, C.. Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis. Nat. Med.. 2018; 24: 1837-1844 [OpenAIRE] [PubMed] [DOI]

Chang, A., Nishiyama, A., Peterson, J., Prineas, J., Trapp, B.D.. NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. J. Neurosci.. 2000; 20: 6404-6412 [OpenAIRE] [PubMed] [DOI]

Prineas, J.W., Kwon, E.E., Goldenberg, P.Z., Ilyas, A.A., Quarles, R.H., Benjamins, J.A., Sprinkle, T.J.. Multiple sclerosis. Oligodendrocyte proliferation and differentiation in fresh lesions. Lab. Investig.. 1989; 61: 489-503 [PubMed]

Lucchinetti, C., Bruck, W., Parisi, J., Scheithauer, B., Rodriguez, M., Lassmann, H.. A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases. Brain. 1999; 122: 2279-2295 [OpenAIRE] [PubMed] [DOI]

Roy, N.S., Wang, S., Harrison-Restelli, C., Benraiss, A., Fraser, R.A., Gravel, M., Braun, P.E., Goldman, S.A.. Identification, isolation, and promoter-defined separation of mitotic oligodendrocyte progenitor cells from the adult human subcortical white matter. J. Neurosci.. 1999; 19: 9986-9995 [OpenAIRE] [PubMed] [DOI]

Lassmann, H.. Comparative neuropathology of chronic experimental allergic encephalomyelitis and multiple sclerosis. Schriftenr. Neurol.. 1983; 25: 1-135 [PubMed]

Schlesinger, H.. Zur Frage der akuten multiplen Sklerose und der encephalomyelitis disseminata im Kindesalter. Arb. Neurol. Inst.. 1909; 17: 410-432

Halfpenny, C., Benn, T., Scolding, N.. Cell transplantation, myelin repair, and multiple sclerosis. Lancet Neurol.. 2002; 1: 31-40 [OpenAIRE] [PubMed] [DOI]

Oksenberg, J.R., Begovich, A.B., Erlich, H.A., Steinman, L.. Genetic factors in multiple sclerosis. Jama. 1993; 270: 2362-2369 [OpenAIRE] [PubMed] [DOI]

Poser, C.M.. The epidemiology of multiple sclerosis: A general overview. Ann. Neurol.. 1994; 36 (Suppl. 2): S180-S193 [OpenAIRE] [PubMed] [DOI]

113 references, page 1 of 8
Related research
Any information missing or wrong?Report an Issue