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Publication . Article . 2018

Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease

Tapan Dey; Jatin Kalita; Sinéad Weldon; Clifford C. Taggart;
Open Access
Published: 01 Aug 2018 Journal: Journal of Clinical Medicine, volume 7, page 244 (eissn: 2077-0383, Copyright policy )
Publisher: MDPI AG
Country: United Kingdom

In the context of respiratory disease, chronic obstructive pulmonary disease (COPD) is the leading cause of mortality worldwide. Despite much development in the area of drug development, currently there are no effective medicines available for the treatment of this disease. An imbalance in the protease: Antiprotease ratio in the COPD lung remains an important aspect of COPD pathophysiology and several studies have shown the efficacy of antiprotease therapy in both in vitro and in vivo COPD models. However more in-depth studies will be required to validate the efficacy of lead drug molecules targeting these proteases. This review discusses the current status of protease-directed drugs used for treating COPD and explores the future prospects of utilizing the potential of antiprotease-based therapeutics as a treatment for this disease.

Subjects by Vocabulary

Microsoft Academic Graph classification: Proteases COPD medicine.disease medicine Lung medicine.anatomical_structure business.industry business Disease Drug development Intensive care medicine medicine.medical_specialty Drug media_common.quotation_subject media_common Respiratory disease Context (language use)

Medical Subject Headings: respiratory tract diseases

Library of Congress Subject Headings: lcsh:Medicine lcsh:R


General Medicine, chronic obstructive pulmonary disease, protease, antiprotease, Review

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