Actions
  • shareshare
  • link
  • cite
  • add
Powered by OpenAIRE graph
Found an issue? Give us feedback
add
auto_awesome_motion View all 5 versions
Publication . Article . 2018

Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease

Tapan Dey; Jatin Kalita; Sinéad Weldon; Clifford C. Taggart;
Open Access
Published: 01 Aug 2018 Journal: Journal of Clinical Medicine, volume 7, page 244 (eissn: 2077-0383, Copyright policy )
Publisher: MDPI AG
Country: United Kingdom
Abstract

In the context of respiratory disease, chronic obstructive pulmonary disease (COPD) is the leading cause of mortality worldwide. Despite much development in the area of drug development, currently there are no effective medicines available for the treatment of this disease. An imbalance in the protease: Antiprotease ratio in the COPD lung remains an important aspect of COPD pathophysiology and several studies have shown the efficacy of antiprotease therapy in both in vitro and in vivo COPD models. However more in-depth studies will be required to validate the efficacy of lead drug molecules targeting these proteases. This review discusses the current status of protease-directed drugs used for treating COPD and explores the future prospects of utilizing the potential of antiprotease-based therapeutics as a treatment for this disease.

Subjects by Vocabulary

Microsoft Academic Graph classification: Proteases COPD medicine.disease medicine Lung medicine.anatomical_structure business.industry business Disease Drug development Intensive care medicine medicine.medical_specialty Drug media_common.quotation_subject media_common Respiratory disease Context (language use)

Medical Subject Headings: respiratory tract diseases

Library of Congress Subject Headings: lcsh:Medicine lcsh:R

Subjects

General Medicine, chronic obstructive pulmonary disease, protease, antiprotease, Review

170 references, page 1 of 17

Lopez, A.D., Shibuya, K., Rao, C., Mathers, C.D., Hansell, A.L., Held, L.S., Schmid, V., Buist, S.. Chronic obstructive pulmonary disease: Current burden and future projections. Eur. Respir. J.. 2006; 27: 397-412 [OpenAIRE] [PubMed] [DOI]

World Health Organization Report: Burden of Chronic Respiratory Disease. 2011

Dalal, A.A., Christensen, L., Liu, F., Riedel, A.A.. Direct costs of chronic obstructive pulmonary disease among managed care patients. Int. J. Chron. Obstr. Pulm. Dis.. 2010; 5: 341-349 [OpenAIRE] [PubMed] [DOI]

Bhome, A.B.. COPD in India: Iceberg or volcano?. J. Thorac. Dis.. 2012; 4: 298-309 [OpenAIRE] [PubMed]

Chen, X., Wang, N., Chen, Y., Xiao, T., Fu, C., Xu, B.. Costs of chronic obstructive pulmonary disease in urban areas of China: A cross-sectional study in four cities. Int. J. Chron. Obstr. Pulm. Dis.. 2016; 11: 2625-2632 [OpenAIRE] [PubMed] [DOI]

Adeloye, D., Chua, S., Lee, C., Basquill, C., Papana, A., Theodoratou, E., Nair, H., Gasevic, D., Sridhar, D., Campbell, H.. Global and regional estimates of COPD prevalence: Systematic review and meta-analysis. J. Glob. Health. 2015; 5: 020415 [OpenAIRE] [PubMed] [DOI]

Nowak, D., Berger, K., Lippert, B., Kilgert, K., Caeser, M., Sandtmann, R.. Epidemiology and health economics of COPD across Europe: A critical analysis. Treat. Respir. Med.. 2005; 4: 381-395 [OpenAIRE] [PubMed] [DOI]

Lahousse, L., Seys, L.J.M., Joos, G.F., Franco, O.H., Stricker, B.H., Brusselle, G.G.. Epidemiology and impact of chronic bronchitis in chronic obstructive pulmonary disease. Eur. Respir. J.. 2017; 50: 1602470 [OpenAIRE] [PubMed] [DOI]

Sharafkhaneh, A., Hanania, N.A., Kim, V.. Pathogenesis of emphysema: From the bench to the bedside. Proc. Am. Thorac. Soc.. 2008; 5: 475-477 [OpenAIRE] [PubMed] [DOI]

Kamal, R., Srivastava, A.K., Kesavachandran, C.N.. Meta-analysis approach to study the prevalence of chronic obstructive pulmonary disease among current, former and non-smokers. Toxicol. Rep.. 2015; 2: 1064-1074 [OpenAIRE] [PubMed] [DOI]

Powered by OpenAIRE graph
Found an issue? Give us feedback
moresidebar