publication . Article . 2021

FibroScan-AST score predicts 30-day mortality or need for mechanical ventilation among patients hospitalized with COVID-19

Marko Zelenika; Marko Lucijanic; Tomislav Bokun; Tonci Bozin; Mislav Barisic Jaman; Ida Tjesic Drinkovic; Frane Pastrovic; Anita Madir; Ivica Lukšić; Nevenka Piskac Zivkovic; ...
Open Access English
  • Published: 24 Sep 2021
Abstract
Background: Liver involvement in Coronavirus disease 2019 (COVID-19) has been recognised. We aimed to investigate the correlation of non-invasive surrogates of liver steatosis, fibrosis and inflammation using transient elastography (TE) and FibroScan-AST (FAST) score with (a) clinical severity and (b) 30-day composite outcome of mechanical ventilation (MV) or death among patients hospitalized due to COVID-19. Method: Patients with non-critical COVID-19 at admission were included. Liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) were assessed by TE. Clinical severity of COVID-19 was assessed by 4C Mortality Score (4CMS) and need for high-flow nasal cannula (HFNC) oxygen supplementation. Results: 217 patients were included (66.5% males, median age 65 years, 4.6% with history of chronic liver disease). Twenty-four (11.1%) patients met the 30-day composite outcome. Median LSM, CAP and FAST score were 5.2 kPa, 274 dB/m and 0.31, respectively, and neither was associated with clinical severity of COVID-19 at admission. In multivariate analysis FAST &gt
0.36 (OR 3.19, p = 0.036), 4CMS (OR 1.68, p = 0.002) and HFNC (OR 7.03, p = 0.001) were independent predictors of adverse composite outcome. Conclusion: Whereas LSM and CAP failed to show correlation with COVID-19 severity and outcomes, FAST score was an independent risk factor for 30-day mortality or need for MV.
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free text keywords: COVID-19, liver, non-alcoholic steatohepatitis, transient elastography, mortality, Medicine, R, Article, COVID-19 ; liver ; non-alcoholic steatohepatitis ; transient elastography ; mortality, General Medicine, Multivariate analysis, Coronavirus disease 2019 (COVID-19), Gastroenterology, medicine.medical_specialty, medicine, Nasal cannula, medicine.disease_cause, Transient elastography, Internal medicine, Chronic liver disease, medicine.disease, Mechanical ventilation, medicine.medical_treatment, Fibrosis, Risk factor, business.industry, business
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