publication . Article . 2021

Severe COVID-19 Lung Infection in Older People and Periodontitis

Ruben Aquino-Martinez; Scarlette Hernández-Vigueras;
Open Access English
  • Published: 14 Jan 2021 Journal: Journal of Clinical Medicine, volume 10, issue 279 (issn: 2077-0383, Copyright policy)
  • Publisher: MDPI AG
Abstract
Periodontal bacteria dissemination into the lower respiratory tract may create favorable conditions for severe COVID-19 lung infection. Once lung tissues are colonized, cells that survive persistent bacterial infection can undergo permanent damage and accelerated cellular senescence. Consequently, several morphological and functional features of senescent lung cells facilitate SARS-CoV-2 replication. The higher risk for severe SARS-CoV-2 infection, the virus that causes COVID-19, and death in older patients has generated the question whether basic aging mechanisms could be implicated in such susceptibility. Mounting evidence indicates that cellular senescence, a...
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free text keywords: periodontitis, periodontal disease, oral bacteria, <i>Porphyromonas gingivalis</i>, LPS, pneumonia, General Medicine, Review, Porphyromonas gingivalis, lung, COVID-19, SARS-CoV-2, cellular senescence, lcsh:Medicine, lcsh:R, Pathogenic bacteria, medicine.disease_cause, medicine, Immunology, Respiratory system, business.industry, business, Porphyromonas gingivalis, biology.organism_classification, biology, Lung, medicine.anatomical_structure, Severe periodontitis, Respiratory tract, Periodontitis, medicine.disease, Virus
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