publication . Article . 2021

Proposal of the Definition for COVID-19-Associated Coagulopathy

Toshiaki Iba; Theodore E. Warkentin; Jecko Thachil; Marcel Levi; Jerrold H. Levy;
Open Access
  • Published: 07 Jan 2021 Journal: Journal of Clinical Medicine, volume 10, page 191 (eissn: 2077-0383, Copyright policy)
  • Publisher: MDPI AG
Thrombotic events are common complications in COVID-19 patients that include both thrombus formation in large vessels and the microvasculature of the lung and other organs. COVID-19-associated coagulopathy (CAC) and disseminated intravascular coagulation (DIC) have similarities and differences, and whether CAC is a form of DIC is the subject of debate. Reported mechanisms of CAC include activated coagulation, endotheliopathy, up-regulated innate and adaptive immunity, and activated complement system. Although the clinical features and laboratory findings of CAC and DIC seem different, there are fundamental similarities that should be considered. Basically, the pathological findings of COVID-19 fall within the scope of the definition of DIC, i.e., systemic activation of coagulation caused by or resulting from the microvascular damage. Therefore, we suggest that although CAC differs from usual infection-associated DIC, its various features indicate that it can be considered a thrombotic phenotype DIC. This review summarizes the current knowledge about CAC including differences and similarities with sepsis-associated DIC.
Persistent Identifiers
Fields of Science and Technology classification (FOS)
03 medical and health sciences, 0302 clinical medicine, 030204 cardiovascular system & hematology, 0303 health sciences, 030304 developmental biology
Sustainable Development Goals (SDG)
2. Zero hunger
Medical Subject Headings: hemic and lymphatic diseasescirculatory and respiratory physiologycardiovascular diseasescardiovascular systemnutritional and metabolic diseases
free text keywords: General Engineering, Review, COVID-19, disseminated intravascular coagulation, endothelial cell, coagulopathy, heparin, Coagulopathy, medicine.disease, medicine, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, business, Pathological, Bioinformatics, Thrombus, Disseminated intravascular coagulation, lcsh:Medicine, lcsh:R
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