publication . Article . 2020

Bovine Interferon Lambda Is a Potent Antiviral Against SARS-CoV-2 Infection in vitro

Nancy Patricia Cardoso; Florencia Celeste Mansilla; Estefanía Benedetti; Cecilia Soledad Turco; Lucas José Barone; Javier Alonso Iserte; Ivana Soria; Elsa Baumeister; Alejandra Victoria Capozzo;
Open Access English
  • Published: 01 Nov 2020 Journal: Frontiers in Veterinary Science, volume 7 (issn: 2297-1769, Copyright policy)
  • Publisher: Frontiers Media S.A.
  • Country: Argentina
Abstract
Interferon lambda (IFN-λ) is an antiviral naturally produced in response to viral infections, with activity on cells of epithelial origin and located in the mucosal surfaces. This localized activity results in reduced toxicity compared to type I IFNs, whose receptors are ubiquitously expressed. IFN-λ has been effective in the therapy of respiratory viral infections, playing a crucial role in potentiating adaptive immune responses that initiate at mucosal surfaces. Human IFN-λ has polymorphisms that may cause differences in the interaction with the specific receptor in the human population. Interestingly, bovine IFN-λ3 has an in silico-predicted higher affinity f...
Subjects
free text keywords: COVID-19, bovine IFN-λ, antivirals, respiratory viruses, biotherapeutic agent, COVID-19, BOVINE INTERFERON, ANTIVIRAL, BIOTHERAPEUTIC AGENT, Otras Biotecnologías de la Salud, Biotecnología de la Salud, CIENCIAS MÉDICAS Y DE LA SALUD, Interferonas, Viricidas, Virus, Interferons, Antiviral Agents, Viruses, In vitro, General Veterinary, Veterinary Science, Original Research, lcsh:Veterinary medicine, lcsh:SF600-1100, Receptor, Proinflammatory cytokine, Virology, Biology, Population, education.field_of_study, education, Immune system, Interferon, medicine.drug, medicine, Biotherapeutic agent, Vero cell, Virus
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