publication . Article . 2020

Ozone Therapy as a Possible Option in COVID-19 Management

Alessandra Gavazza; Andrea Marchegiani; Giacomo Rossi; Marianno Franzini; Marianno Franzini; Andrea Spaterna; Sara Mangiaterra; Matteo Cerquetella;
Open Access English
  • Published: 25 Aug 2020 Journal: Frontiers in Public Health, volume 8 (eissn: 2296-2565, Copyright policy)
  • Publisher: Frontiers Media S.A.
  • Country: Italy
Persistent Identifiers
Subjects
free text keywords: Public Health, Opinion, COVID-19, ozone, SARS-CoV-2, therapy, Public Health, Environmental and Occupational Health, Ozone therapy, Medicine, business.industry, business, 2019-20 coronavirus outbreak, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Coronavirus disease 2019 (COVID-19), Virology, lcsh:Public aspects of medicine, lcsh:RA1-1270
32 references, page 1 of 3

1. CDC - How Coronavirus Spreads. Available online at: https://www.cdc. gov/coronavirus/2019-ncov/prevent-getting-sick/how-covid-spreads.html (accessed March 31, 2020).

2. Adhikari SP, Meng S, Wu YJ, Mao YP, Ye RX, Wang QZ, et al. Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review. Infect Dis Poverty. (2020) 9:29. doi: 10.1186/s40249-020-00646-x

3. Li H, Zhou Y, Zhang M, Wang H, Zhao Q, Liu J. Updated approaches against SARS-CoV-2. Antimicrob Agents Chemother. (2020) 9:382-5. doi: 10.1128/AAC.00483-20

4. Guo Y-R, Cao Q-D, Hong Z-S, Tan Y-Y, Chen S-D, Jin H-J, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res. (2020) 7:1- 10. doi: 10.1186/s40779-020-00240-0

5. Bocci VA. Scientific and medical aspects of ozone therapy. State Art Arch Med Res. (2006) 37:425-35. doi: 10.1016/j.arcmed.2005.08.006 [OpenAIRE]

6. Elvis AM, Ekta JS. Ozone therapy: a clinical review. J Nat Sci Biol Med. (2011) 2:66-70. doi: 10.4103/0976-9668.82319 [OpenAIRE]

7. Glew RH, Basu A, Shelley SA, Paterson JF, Diven WF, Montgomery MR, et al. Sequential changes of lamellar body hydrolases during ozone-induced alveolar injury and repair. Am J Pathol. (1989) 134:1143-50. [OpenAIRE]

8. Balis JU, Paterson JF, Lundh JM, Haller EM, Shelley SA, Montgomery MR. Ozone stress initiates acute perturbations of secreted surfactant membranes. Am J Pathol. (1991) 138:847-57. [OpenAIRE]

9. Valacchi G, Fortino V, Bocci V. The dual action of ozone on the skin. Br J Dermatol. (2005) 153:1096-100. doi: 10.1111/j.1365-2133.2005.06939.x

10. Martínez-Sánchez G, Schwartz A, Donna VD. Potential cytoprotective activity of ozone therapy in SARS-CoV-2/COVID-19. Antioxidants (Basel). (2020) 9:389. doi: 10.3390/antiox9050389

11. Valdenassi L, Franzini M, Ricevuti G, Rinaldi L, Galoforo AC, Tirelli U. Potential mechanisms by which the oxygen-ozone (O2-O3) therapy could contribute to the treatment against the coronavirus COVID-19. Eur Rev Med Pharmacol Sci. (2020) 24:4059-61. doi: 10.26355/eurrev_202004_20976 [OpenAIRE]

12. Larini A, Bianchi L, Bocci V. The ozone tolerance: I) Enhancement of antioxidant enzymes is ozone dose-dependent in Jurkat cells. Free Radic Res. (2003) 37:1163-8. doi: 10.1080/10715760310001604170

13. Sechi LA, Lezcano I, Nunez N, Espim M, Dupre I, Pinna A, et al. Antibacterial activity of ozonized sunflower oil (Oleozon). J Appl Microbiol. (2001) 90:279- 84. doi: 10.1046/j.1365-2672.2001.01235.x

14. Wentworth P, McDunn JE, Wentworth AD, Takeuchi C, Nieva J, Jones T, et al. Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation. Science. (2002) 298:2195-9. doi: 10.1126/science.1077642

15. Ouf SA, Moussa TA, Abd-Elmegeed AM, Eltahlawy SR. Anti-fungal potential of ozone against some dermatophytes. Brazilian J Microbiol. (2016) 47:697- 702. doi: 10.1016/j.bjm.2016.04.014 [OpenAIRE]

32 references, page 1 of 3
Persistent Identifiers
Subjects
free text keywords: Public Health, Opinion, COVID-19, ozone, SARS-CoV-2, therapy, Public Health, Environmental and Occupational Health, Ozone therapy, Medicine, business.industry, business, 2019-20 coronavirus outbreak, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Coronavirus disease 2019 (COVID-19), Virology, lcsh:Public aspects of medicine, lcsh:RA1-1270
32 references, page 1 of 3

1. CDC - How Coronavirus Spreads. Available online at: https://www.cdc. gov/coronavirus/2019-ncov/prevent-getting-sick/how-covid-spreads.html (accessed March 31, 2020).

2. Adhikari SP, Meng S, Wu YJ, Mao YP, Ye RX, Wang QZ, et al. Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review. Infect Dis Poverty. (2020) 9:29. doi: 10.1186/s40249-020-00646-x

3. Li H, Zhou Y, Zhang M, Wang H, Zhao Q, Liu J. Updated approaches against SARS-CoV-2. Antimicrob Agents Chemother. (2020) 9:382-5. doi: 10.1128/AAC.00483-20

4. Guo Y-R, Cao Q-D, Hong Z-S, Tan Y-Y, Chen S-D, Jin H-J, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res. (2020) 7:1- 10. doi: 10.1186/s40779-020-00240-0

5. Bocci VA. Scientific and medical aspects of ozone therapy. State Art Arch Med Res. (2006) 37:425-35. doi: 10.1016/j.arcmed.2005.08.006 [OpenAIRE]

6. Elvis AM, Ekta JS. Ozone therapy: a clinical review. J Nat Sci Biol Med. (2011) 2:66-70. doi: 10.4103/0976-9668.82319 [OpenAIRE]

7. Glew RH, Basu A, Shelley SA, Paterson JF, Diven WF, Montgomery MR, et al. Sequential changes of lamellar body hydrolases during ozone-induced alveolar injury and repair. Am J Pathol. (1989) 134:1143-50. [OpenAIRE]

8. Balis JU, Paterson JF, Lundh JM, Haller EM, Shelley SA, Montgomery MR. Ozone stress initiates acute perturbations of secreted surfactant membranes. Am J Pathol. (1991) 138:847-57. [OpenAIRE]

9. Valacchi G, Fortino V, Bocci V. The dual action of ozone on the skin. Br J Dermatol. (2005) 153:1096-100. doi: 10.1111/j.1365-2133.2005.06939.x

10. Martínez-Sánchez G, Schwartz A, Donna VD. Potential cytoprotective activity of ozone therapy in SARS-CoV-2/COVID-19. Antioxidants (Basel). (2020) 9:389. doi: 10.3390/antiox9050389

11. Valdenassi L, Franzini M, Ricevuti G, Rinaldi L, Galoforo AC, Tirelli U. Potential mechanisms by which the oxygen-ozone (O2-O3) therapy could contribute to the treatment against the coronavirus COVID-19. Eur Rev Med Pharmacol Sci. (2020) 24:4059-61. doi: 10.26355/eurrev_202004_20976 [OpenAIRE]

12. Larini A, Bianchi L, Bocci V. The ozone tolerance: I) Enhancement of antioxidant enzymes is ozone dose-dependent in Jurkat cells. Free Radic Res. (2003) 37:1163-8. doi: 10.1080/10715760310001604170

13. Sechi LA, Lezcano I, Nunez N, Espim M, Dupre I, Pinna A, et al. Antibacterial activity of ozonized sunflower oil (Oleozon). J Appl Microbiol. (2001) 90:279- 84. doi: 10.1046/j.1365-2672.2001.01235.x

14. Wentworth P, McDunn JE, Wentworth AD, Takeuchi C, Nieva J, Jones T, et al. Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation. Science. (2002) 298:2195-9. doi: 10.1126/science.1077642

15. Ouf SA, Moussa TA, Abd-Elmegeed AM, Eltahlawy SR. Anti-fungal potential of ozone against some dermatophytes. Brazilian J Microbiol. (2016) 47:697- 702. doi: 10.1016/j.bjm.2016.04.014 [OpenAIRE]

32 references, page 1 of 3
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