publication . Article . 2016

Antibody Response and Disease Severity in Healthcare Worker MERS Survivors

Abeer N. Alshukairi; Imran Khalid; Waleed A. Ahmed; Ashraf Dada; Daniyah T. Bayumi; Laut S. Malic; Sahar Althawadi; Kim Ignacio; Hanadi Alsalmi; Hail M. Al-Abdely; ...
Open Access
  • Published: 01 Jun 2016
  • Publisher: Centers for Disease Control and Prevention (CDC)
We studied antibody response in 9 healthcare workers in Jeddah, Saudi Arabia, who survived Middle East respiratory syndrome, by using serial ELISA and indirect immunofluorescence assay testing. Among patients who had experienced severe pneumonia, antibody was detected for >18 months after infection. Antibody longevity was more variable in patients who had experienced milder disease.
Persistent Identifiers
free text keywords: Dispatch, Antibody Response and Disease Severity in Healthcare Worker MERS Survivors, antibody, Middle East respiratory syndrome coronavirus, MERS-CoV, ELISA, indirect immunofluorescence assay, IFA, healthcare workers, immune response, viruses, Jeddah, Saudi Arabia, lcsh:Medicine, lcsh:R, lcsh:Infectious and parasitic diseases, lcsh:RC109-216, Disease, Middle East respiratory syndrome coronavirus, medicine.disease_cause, medicine, Severity of illness, Immune system, Middle East respiratory syndrome, medicine.disease, Viral shedding, Antibody response, Immunology, Internal medicine, medicine.medical_specialty, business.industry, business, Antibody, biology.protein, biology
Funded by
NIH| Animal Core
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P01AI060699-10

1. Liu W, Fontanet A, Zhang PH, Zhan L, Xin ZT, Baril L, Two-year prospective study of the humoral immune response of patients with severe acute respiratory syndrome.J Infect Dis. 2006;193:792–5 . 10.1086/500469 16479513 [OpenAIRE] [PubMed] [DOI]

2. Tang F, Quan Y, Xin ZT, Wrammert J, Ma MJ, Lv H, Lack of peripheral memory B cell responses in recovered patients with severe acute respiratory syndrome: a six-year follow-up study.J Immunol. 2011;186:7264–8. 10.4049/jimmunol.0903490 21576510 [OpenAIRE] [PubMed] [DOI]

3. Corman VM, Albarrak AM, Omrani AS, Albarrak MM, Farah ME, Almasri M, Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection.Clin Infect Dis. 2016;62:477–83 .26565003 [OpenAIRE] [PubMed]

4. Park WB, Perera RA, Choe PG, Lau EH, Choi SJ, Chun JY, Kinetics of serologic responses to MERS coronavirus infection in humans, South Korea.Emerg Infect Dis. 2015;21:2186–9. 10.3201/eid2112.151421 26583829 [OpenAIRE] [PubMed] [DOI]

5. Buchholz U, Müller MA, Nitsche A, Sanewski A, Wevering N, Bauer-Balci T, Contact investigation of a case of human novel coronavirus infection treated in a German hospital, October–November 2012.Euro Surveill. 2013;18:20406 .23449231 [PubMed]

6. Corman VM, Müller MA, Costabel U, Timm J, Binger T, Meyer B, Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections.Euro Surveill. 2012;17:20334 .23231891 [OpenAIRE] [PubMed]

7. Al-Abdallat MM, Payne DC, Alqasrawi S, Rha B, Tohme RA, Abedi GR, Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description.Clin Infect Dis. 2014;59:1225–33. 10.1093/cid/ciu359 24829216 [OpenAIRE] [PubMed] [DOI]

8. Drosten C, Meyer B, Müller MA, Corman VM, Al-Masri M, Hossain R, Transmission of MERS-coronavirus in household contacts.N Engl J Med. 2014;371:828–35. 10.1056/NEJMoa1405858 25162889 [PubMed] [DOI]

9. Channappanavar R, Fett C, Zhao J, Meyerholz DK, Perlman S. Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection.J Virol. 2014;88:11034–44. 10.1128/JVI.01505-14 25056892 [OpenAIRE] [PubMed] [DOI]

10. Meyer B, Drosten C, Müller MA. Serological assays for emerging coronaviruses: challenges and pitfalls.Virus Res. 2014;194:175–83. 10.1016/j.virusres.2014.03.018 24670324 [OpenAIRE] [PubMed] [DOI]

11. Müller MA, Meyer B, Corman VM, Al-Masri M, Turkestani A, Ritz D, Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study.Lancet Infect Dis. 2015;15:559–64. 10.1016/S1473-3099(15)70090-3 25863564 [OpenAIRE] [PubMed] [DOI]

12. Aburizaiza AS, Mattes FM, Azhar EI, Hassan AM, Memish ZA, Muth D, Investigation of anti-middle East respiratory syndrome antibodies in blood donors and slaughterhouse workers in Jeddah and Makkah, Saudi Arabia, fall 2012.J Infect Dis. 2014;209:243–6. 10.1093/infdis/jit5 89 24218504 [OpenAIRE] [PubMed] [DOI]

Any information missing or wrong?Report an Issue