publication . Other literature type . Article . 2020

A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19

Yadi Zhou; Yuan Hou; Jiayu Shen; Asha Kalianpur; Joe Zein; Daniel A. Culver; Samar Farha; Suzy Comhair; Claudio Fiocchi; Michaela U. Gack; ...
Open Access
  • Published: 01 Nov 2020
  • Publisher: American Chemical Society (ACS)
The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to unprecedented social and economic consequences. The risk of morbidity and mortality due to COVID-19 increases dramatically in the presence of coexisting medical conditions, while the underlying mechanisms remain unclear. Furthermore, there are no approved therapies for COVID-19. This study aims to identify SARS-CoV-2 pathogenesis, disease manifestations, and COVID-19 therapies using network medicine methodologies along with clinical and multi-omics observations. We incorporate SARS-CoV-2 virus–host protein–protein interactio...
free text keywords: Biology (General), QH301-705.5, Research Article, Medicine and Health Sciences, Medical Conditions, Infectious Diseases, Viral Diseases, Covid 19, Biology and life sciences, Organisms, Viruses, RNA viruses, Coronaviruses, SARS coronavirus, SARS CoV 2, Microbiology, Medical microbiology, Microbial pathogens, Viral pathogens, Pathology and laboratory medicine, Pathogens, Respiratory Disorders, Asthma, Pulmonology, Computer and Information Sciences, Network Analysis, Protein Interaction Networks, Biochemistry, Proteomics, Molecular Biology, Interaction Networks, Hormones, Melatonin, Cell Biology, Cellular Types, Animal Cells, Epithelial Cells, Anatomy, Biological Tissue, Epithelium, Diagnostic Medicine, Virus Testing, Article
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