publication . Article . Other literature type . 2010

The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity.

Martina Beltramello; Katherine L. Williams; Cameron P. Simmons; Annalisa Macagno; Luca Simonelli; Nguyen Than Ha Quyen; Soila Sukupolvi-Petty; Erika Navarro-Sanchez; Paul R. Young; Aravinda M. de Silva; ...
Open Access English
  • Published: 16 Sep 2010 Journal: Cell host and microbe, volume 8, issue 3 (issn: 1931-3128, eissn: 1934-6069, Copyright policy)
International audience; Antibodies protect against homologous Dengue virus (DENV) infection but can precipitate severe dengue by promoting heterotypic virus entry via Fcγ receptors (FcγR). We immortalized memory B cells from individuals after primary or secondary infection and analyzed anti-DENV monoclonal antibodies (mAbs) thus generated. MAbs to envelope (E) protein domain III (DIII) were either serotype specific or cross-reactive and potently neutralized DENV infection. DI/DII- or viral membrane protein prM-reactive mAbs neutralized poorly and showed broad cross-reactivity with the four DENV serotypes. All mAbs enhanced infection at subneutralizing concentrat...
Medical Subject Headings: virusesvirus diseasesbiochemical phenomena, metabolism, and nutrition
free text keywords: [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Virology, Microbiology, Parasitology, Immunology and Microbiology(all), Cancer Research, Molecular Biology, Article, Dengue virus, medicine.disease_cause, medicine, Viral membrane, Biology, Virology, Dengue fever, medicine.disease, Epitope, Viral entry, Secondary infection, Monoclonal antibody, medicine.drug_class, Antibody-dependent enhancement
Funded by
  • Funder: Wellcome Trust (WT)
SNSF| The role of innate receptors in dendritic cell and B lymphocyte activation
  • Funder: Swiss National Science Foundation (SNSF)
  • Project Code: 31003AB-126027
  • Funding stream: Project funding | Project funding (Div. I-III)
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