publication . Article . 2014

Multi-Organ Lesions in Suckling Mice Infected with SARS-Associated Mammalian Reovirus Linked with Apoptosis Induced by Viral Proteins μ1 and σ1

Lihua Song; Yongfeng Lu; Jun He; Yonghui Yu; Tingting Zuo; Yanwei Li; Hong Zhu; Qing Duan;
Open Access
  • Published: 24 Mar 2014 Journal: PLoS ONE, volume 9, issue 3 (eissn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science (PLoS)
Abstract
We reported the isolation and characterization of a novel mammalian reassortant reovirus BYD1 that may have played an accomplice role with SARS-coronavirus during the 2003 SARS pandemic. The pathogenic mechanism of this novel reovirus is unknown. Reovirus pathogenicity has been associated with virus-induced apoptosis in cultured cells and in vivo. The reovirus outer capsid protein μ1 is recognized as the primary determinant of reovirus-induced apoptosis. Here, we investigated the apoptosis induced by BYD1, its outer capsid protein μ1, and its cell-attachment protein σ1 to understand the pathogenesis of BYD1. We also investigated BYD1 caused systemic complication...
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Subjects
Medical Subject Headings: viruses
free text keywords: General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine, Research Article, Biology and Life Sciences, Cell Biology, Cell Processes, Cell Death, Molecular Cell Biology, Microbiology, Virology, Viral Transmission and Infection, Animal Models of Infection, Medicine and Health Sciences, Infectious Diseases, Viral Diseases, SARS, Pathology and Laboratory Medicine, Pathogens, Virulence Factors, Public and Occupational Health, Research and Analysis Methods, Model Organisms, Animal Models, Mouse Models, Science Policy, Science Education, lcsh:Medicine, lcsh:R, lcsh:Science, lcsh:Q, Myocarditis, medicine.disease, medicine, Mammalian reovirus, Virulence, Pathogenesis, Apoptosis, Biology, HEK 293 cells, Reoviridae, biology.organism_classification, In vivo, Virology
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