publication . Article . 2021

Management of Renin-Angiotensin-Aldosterone System blockade in patients admitted to hospital with confirmed coronavirus disease (COVID-19) infection (The McGill RAAS-COVID- 19): A structured summary of a study protocol for a randomized controlled trial

Mona Aflaki; Alexandria Flannery; João Pedro Ferreira; Matthew P Cheng; Nadine Kronfli; Ariane Marelli; Faiez Zannad; James M. Brophy; Jon Afillalo; Thao Huynh; ...
Open Access English
  • Published: 01 Dec 2021
  • Publisher: HAL CCSD
  • Country: France
Abstract
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Objectives</jats:title> <jats:p>The aim of the RAAS-COVID-19 randomized control trial is to evaluate whether an upfront strategy of temporary discontinuation of renin angiotensin aldosterone system (RAAS) inhibition versus continuation of RAAS inhibition among patients admitted with established COVID-19 infection has an impact on short term clinical and biomarker outcomes. We hypothesize that continuation of RAAS inhibition will be superior to temporary discontinuation with regards to the primary endpoint of a global rank sum score. The global rank sum score has been successfully used in previous cardiovasc...
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free text keywords: ACE inhibitor, ACE2, COVID-19, Cardiovascular disease, Mortality, Protocol, RAAS inhibitor, Randomised controlled trial, SARS- CoV2, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Study Protocol, Medicine (miscellaneous), Pharmacology (medical), lcsh:Medicine (General), lcsh:R5-920, Clinical trial, Cohort, Discontinuation, Superiority Trial, Inclusion and exclusion criteria, Clinical endpoint, Randomized controlled trial, law.invention, law, Medicine, business.industry, business, Randomization, Emergency medicine, medicine.medical_specialty
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  • Funder: Natural Sciences and Engineering Research Council of Canada (NSERC)
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COVID-19
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