publication . Article . 2021

Management of Renin-Angiotensin-Aldosterone System blockade in patients admitted to hospital with confirmed coronavirus disease (COVID-19) infection (The McGill RAAS-COVID- 19): A structured summary of a study protocol for a randomized controlled trial

Mona Aflaki; Alexandria Flannery; João Pedro Ferreira; Matthew P Cheng; Nadine Kronfli; Ariane Marelli; Faiez Zannad; James M. Brophy; Jon Afillalo; Thao Huynh; ...
Open Access English
  • Published: 01 Dec 2021 Journal: Trials, volume 22, issue 1, pages 1-3 (issn: 1745-6215, Copyright policy)
  • Publisher: BMC
  • Country: France
Abstract
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Objectives</jats:title> <jats:p>The aim of the RAAS-COVID-19 randomized control trial is to evaluate whether an upfront strategy of temporary discontinuation of renin angiotensin aldosterone system (RAAS) inhibition versus continuation of RAAS inhibition among patients admitted with established COVID-19 infection has an impact on short term clinical and biomarker outcomes. We hypothesize that continuation of RAAS inhibition will be superior to temporary discontinuation with regards to the primary endpoint of a global rank sum score. The global rank sum score has been successfully used in previous cardiovasc...
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free text keywords: COVID-19, Randomised controlled trial, Protocol, SARS- CoV2, RAAS inhibitor, ACE2, ACE inhibitor, Cardiovascular disease, Mortality, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Pharmacology (medical), Medicine (miscellaneous), Study Protocol, lcsh:Medicine (General), lcsh:R5-920, Medicine, business.industry, business, Randomization, Clinical endpoint, Inclusion and exclusion criteria, Randomized controlled trial, law.invention, law, Superiority Trial, Emergency medicine, medicine.medical_specialty, Cohort, Clinical trial, Discontinuation
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  • Funder: Natural Sciences and Engineering Research Council of Canada (NSERC)
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COVID-19
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