publication . Article . 2015

Genomic analysis of codon usage shows influence of mutation pressure, natural selection, and host features on Marburg virus evolution

Izza Nasrullah; Azeem Mehmood Butt; Shifa Tahir; Muhammad Idrees; Yigang Tong;
Open Access English
  • Published: 26 Aug 2015
  • Publisher: HAL CCSD
  • Country: France
Abstract
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>The Marburg virus (MARV) has a negative-sense single-stranded RNA genome, belongs to the family <jats:italic>Filoviridae</jats:italic>, and is responsible for several outbreaks of highly fatal hemorrhagic fever. Codon usage patterns of viruses reflect a series of evolutionary changes that enable viruses to shape their survival rates and fitness toward the external environment and, most importantly, their hosts. To understand the evolution of MARV at the codon level, we report a comprehensive analysis of synonymous codon usage patterns in MARV genomes. Multiple codon analysis ...
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Subjects
free text keywords: virus de marburg, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Ecology, Evolution, Behavior and Systematics, Autre (Sciences du Vivant), Virologie, Virology, analyse génomique, usage des codons, virus, filovirus, fièvre hémorragique, Research Article, Marburgvirus, biology.organism_classification, biology, Mutation, medicine.disease_cause, medicine, Filoviridae, Natural selection, Evolutionary biology, Molecular evolution, Homo sapiens, Codon usage bias, Genetics, Genome
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