publication . Article . Other literature type . 2019

Junín Virus Promotes Autophagy To Facilitate the Virus Life Cycle

Roldán, Julieta S.; Candurra, Nélida A.; Colombo, María I.; Delgui, Laura R.;
Open Access
  • Published: 17 Jul 2019
  • Publisher: American Society for Microbiology
  • Country: Argentina
Junín virus (JUNV), a member of the family Arenaviridae, is the etiological agent of Argentine hemorrhagic fever (AHF), a potentially deadly endemic-epidemic disease affecting the population of the most fertile farming land of Argentina. Autophagy is a degradative process with a crucial antiviral role; however, several viruses subvert the pathway to their benefit. We determined the role of autophagy in JUNV-infected cells by analyzing LC3, a cytoplasmic protein (LC3-I) that becomes vesicle membrane associated (LC3-II) upon induction of autophagy. Cells overexpressing enhanced green fluorescent protein (EGFP)-LC3 and infected with JUNV showed an increased number ...
Persistent Identifiers
free text keywords: Virology, Insect Science, Immunology, Microbiology, ARENAVIRIDAE, AUTOPHAGY, BECLIN 1, INNATE IMMUNITY, JUNÍN VIRUS, PROVIRAL ROLE, REPLICATION, Virología, Ciencias Biológicas, CIENCIAS NATURALES Y EXACTAS, Virus-Cell Interactions, Arenavirus, biology.organism_classification, biology, Cellular homeostasis, Autophagy, ATG5, Viral life cycle, Virology, Junin virus, Virus, Argentine hemorrhagic fever, medicine.disease, medicine
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