publication . Article . 2020

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Paul Bastard; Lindsey B. Rosen; Qian Zhang; Eleftherios Michailidis; Hans-Heinrich Hoffmann; Yu Zhang; Karim Dorgham; Quentin Philippot; Jérémie Rosain; Vivien Béziat; ...
Open Access English
  • Published: 23 Oct 2020
Abstract
COVID Human Genetic Effort Laurent Abel1, Alessandro Aiuti2, Saleh Al Muhsen3, Fahd Al-Mulla4, Mark S. Anderson5, Andrés Augusto Arias6, Hagit Baris Feldman7, Dusan Bogunovic8, Alexandre Bolze9, Anastasiia Bondarenko10, Ahmed A. Bousfiha11, Petter Brodin12, Yenan Bryceson12, Carlos D. Bustamante13, Manish Butte14, Giorgio Casari15, Samya Chakravorty16, John Christodoulou17, Elizabeth Cirulli9, Antonio Condino Neto18, Megan A. Cooper19, Clifton L. Dalgard20, Joseph L. DeRisi21, Murkesh Desai22, Beth A. Drolet23, Sara Espinosa24, Jacques Fellay25, Carlos Flores26, Jose Luis Franco27, Peter K. Gregersen28, Filomeen Haerynck29, David Hagin30, Rabih Halwani​31, Jim H...
Subjects
free text keywords: [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Adult, MESH: Aged, MESH: Humans, MESH: Immunoglobulin G, MESH: Interferon alpha-2, MESH: Interferon Type I, MESH: Male, MESH: Pandemics, MESH: Middle Aged, MESH: Pneumonia, Viral, MESH: Aged, 80 and over, MESH: SARS-CoV-2, MESH: Asymptomatic Infections, MESH: Antibodies, Neutralizing, MESH: Autoantibodies, MESH: COVID-19, MESH: Betacoronavirus, MESH: Case-Control Studies, MESH: Critical Illness, MESH: Coronavirus Infections, MESH: Female, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], General, Adult, Aged, Aged, 80 and over, Antibodies, Neutralizing, Asymptomatic Infections, Autoantibodies, Betacoronavirus, COVID-19, Case-Control Studies, Coronavirus Infections, Critical Illness, Female, Humans, Immunoglobulin G, Interferon Type I, Interferon alpha-2, Male, Middle Aged, Pandemics, Pneumonia, Viral, SARS-CoV-2, HGID Lab, NIAID-USUHS Immune Response to COVID Group, COVID Clinicians, COVID-STORM Clinicians, Imagine COVID Group, French COVID Cohort Study Group, Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank, COVID Human Genetic Effort, General Science & Technology, Research Article, Research Articles, R-Articles, Genetics, Immunology, Online, Sciences exactes et naturelles, Multidisciplinary, CHRONIC MUCOCUTANEOUS CANDIDIASIS, INTERFERON, ANTIBODIES, DISEASE, CYTOKINES, PROTEINS, GAMMA, 3121 Internal medicine, 3111 Biomedicine, B cell, medicine.anatomical_structure, medicine, business.industry, business, Asymptomatic, medicine.symptom, Disease, Antibody, biology.protein, biology, Case-control study, Autoantibody, Phenocopy, Immunity, Immunology
Related Organizations
Funded by
NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5UL1TR001866-03
  • Funding stream: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
,
ANR| IFN-COVID19
Project
IFN-COVID19
Studying how the type I Interferon response control SARS-Cov2 and its pathogenesis
  • Funder: French National Research Agency (ANR) (ANR)
  • Project Code: ANR-20-COVI-0064
,
NIH| Type I interferon-stimulated genes and the antiviral immune response
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AI091707-05
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| NHGRI Genome Sequencing Program Coordinating Center
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U24HG008956-02
  • Funding stream: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
,
NIH| Yale Center for Mendelian Genomics
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5UM1HG006504-07
  • Funding stream: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
Communities
COVID-19

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