publication . Article . Other literature type . Preprint . 2019

Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling

Landi, Alessia; Mari, Muriel; Kleiser, Svenja; Wolf, Tobias; Gretzmeier, Christine; Wilhelm, Isabel; Kiritsi, Dimitra; Thünauer, Roland; Geiger, Roger; Nyström, Alexander; ...
Open Access
  • Published: 15 Nov 2019
  • Publisher: Life Science Alliance, LLC
  • Country: Netherlands
Abstract
Lectins are glycan-binding proteins with no catalytic activity and ubiquitously expressed in nature. Numerous bacteria use lectins to efficiently bind to epithelia, thus facilitating tissue colonisation. Wounded skin is one of the preferred niches for Pseudomonas aeruginosa, which has developed diverse strategies to impair tissue repair processes and promote infection. Here, we analyse the effect of the P. aeruginosa fucose-binding lectin LecB on human keratinocytes and demonstrate that it triggers events in the host, upon binding to fucosylated residues on cell membrane receptors, which extend beyond its role as an adhesion molecule. We found that LecB associat...
Subjects
free text keywords: Health, Toxicology and Mutagenesis, Plant Science, Biochemistry, Genetics and Molecular Biology (miscellaneous), Ecology, Research Article, Research Articles, 4, 16, Cell cycle, Intracellular, Growth factor, medicine.medical_treatment, medicine, Chemistry, Endosome, Cell membrane, medicine.anatomical_structure, Receptor, Lectin, biology.protein, biology, Cell biology, Keratinocyte, Virulence factor, Growth factor receptor
Communities
  • COVID-19
  • Social Science and Humanities
Funded by
EC| LEC&LIP2INVADE
Project
LEC&LIP2INVADE
The interactions of the Pseudomonas aeruginosa lectins LecA and LecB with glycosphingolipids result in membrane invagination, signaling and cellular uptake of the bacterium
  • Funder: European Commission (EC)
  • Project Code: 282105
  • Funding stream: FP7 | SP2 | ERC
,
EC| DRIVE
Project
DRIVE
Driving next generation autophagy researchers towards translation
  • Funder: European Commission (EC)
  • Project Code: 765912
  • Funding stream: H2020 | MSCA-ITN-ETN
,
NWO| A three-dimensional look into autophagy
Project
  • Funder: Netherlands Organisation for Scientific Research (NWO) (NWO)
  • Project Code: 2300175771
,
EC| PRONKJEWAIL
Project
PRONKJEWAIL
Protecting patients with enhanced susceptibility to infections
  • Funder: European Commission (EC)
  • Project Code: 713660
  • Funding stream: H2020 | MSCA-COFUND-DP
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NARCIS
Article . 2019
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Life Science Alliance
Article . 2019
Provider: NARCIS
Open Access
bioRxiv
Preprint . 2019
Provider: bioRxiv

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