publication . Article . Other literature type . 2021

Improved diagnosis of SARS-CoV-2 by using nucleoprotein and spike protein fragment 2 in quantitative dual ELISA tests

Carolina De M. Verissimo; Carol O’Brien; Jesús López Corrales; Amber Dorey; Krystyna Cwiklinski; Richard Lalor; Jack M. Doyle; Stephen Field; Claire Masterson; Eduardo Ribes Martinez; ...
Open Access English
  • Published: 01 Jun 2021
  • Publisher: Cambridge University Press
  • Country: Ireland
The novel coronavirus, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), is the causative agent of the 2020 worldwide coronavirus pandemic. Antibody testing is useful for diagnosing historic infections of a disease in a population. These tests are also a helpful epidemiological tool for predicting how the virus spreads in a community, relating antibody levels to immunity and for assessing herd immunity. In the present study, SARS-CoV-2 viral proteins were recombinantly produced and used to analyse serum from individuals previously exposed, or not, to SARS-CoV-2. The nucleocapsid (Npro) and spike subunit 2 (S2Frag) proteins were identified as highly i...
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Medical Subject Headings: viruses
free text keywords: COVID-19, diagnosis, nucleocapsid protein, SARS-CoV-2, spike protein, Original Paper
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