publication . Preprint . Article . Other literature type . 2021

Lower respiratory tract myeloid cells harbor SARS-CoV-2 and display an inflammatory phenotype

William Bain; Hernán F. Peñaloza; Mark S. Ladinsky; Rick van der Geest; Mara L. Sullivan; Mark A. Ross; Georgios D Kitsios; Barbara Methé; Bryan J. McVerry; Alison Morris; ...
Open Access
  • Published: 01 Mar 2021
  • Publisher: Cold Spring Harbor Laboratory
  • Country: United States
<jats:title>Abstract</jats:title><jats:p>SARS-CoV-2 pneumonia may induce an aberrant immune response with brisk recruitment of myeloid cells into the lower respiratory tract, which may contribute to morbidity and mortality. We describe endotracheal aspirate samples from seven patients with SARS-CoV-2 pneumonia requiring mechanical ventilation. We note SARS-CoV-2 virions within lower respiratory tract myeloid cells shown by electron tomography, immunofluorescence confocal imaging, and immuno-electron microscopy. Endotracheal aspirates are primarily composed of mononuclear and polymorphonuclear leukocytes. These myeloid cells that harbor virus are frequently posit...
free text keywords: Research Letter, BD, Becton Dickinson, CD, cluster of differentiation, ETA, endotracheal aspirate, IL, interleukin, IRB, institutional review board, RT-PCR, reverse transcriptase polymerase chain reaction, SARS-CoV, severe acute respiratory syndrome coronavirus, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, Pulmonary and Respiratory Medicine, Article, Medicine, business.industry, business, CD16, Respiratory tract, medicine.anatomical_structure, CD14, Tissue factor, Immunology, Immunofluorescence, medicine.diagnostic_test, Phenotype, Immune system, Virus
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