publication . Preprint . Article . 2021

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis

Mariana Galvão Ferrarini; Avantika Lal; Rita Rebollo; Andreas J. Gruber; Andrea Guarracino; Itziar Martinez Gonzalez; Taylor Floyd; Daniel Siqueira de Oliveira; Justin Shanklin; Ethan Beausoleil; ...
Open Access
  • Published: 01 Dec 2021
  • Publisher: Cold Spring Harbor Laboratory
  • Country: France
Abstract
Ferrarini & Lal et al. developed a novel bioinformatic pipeline to explore how SARS-CoV-2 interacts with human respiratory cells using public available host gene expression and viral genome sequence data. Several human genes and proteins were predicted to play a role in the viral life cycle and the host response to SARS-CoV-2 infection.
Subjects
Medical Subject Headings: fungi
free text keywords: [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Article, SARS-CoV-2, RNA, Computational biology and bioinformatics, Transcriptomics, Viral infection, Biology (General), QH301-705.5, General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology, Medicine (miscellaneous), Viral life cycle, DNA sequencing, Genetics, Betacoronavirus, biology.organism_classification, biology, RNA, Genome, Transposable element, Polymerase, biology.protein, Disease
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