publication . Article . 2018

Ultrapotent Human Neutralizing Antibody Repertoires Against Middle East Respiratory Syndrome Coronavirus From a Recovered Patient

Peihua Niu; Senyan Zhang; Panpan Zhou; Baoying Huang; Yao Deng; Kun Qin; Pengfei Wang; Wenling Wang; Xinquan Wang; Jianfang Zhou; ...
Open Access
  • Published: 01 May 2018 Journal: The Journal of Infectious Diseases, volume 218, pages 1,249-1,260 (issn: 0022-1899, eissn: 1537-6613, Copyright policy)
  • Publisher: Oxford University Press (OUP)
Abstract
We describe the MERS-CoV-neutralizing antibody repertoires from a survivor and characterized 13 ultrapotent mAbs. The mAbs, MERS-GD27 and MERS-GD33, exhibited the strongest neutralizing activities. Both targeted receptor-binding domain via different contacts. The epitopes of MERS-GD27 overlapped with DPP4-binding sites.
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Subjects
free text keywords: Immunology and Allergy, Infectious Diseases, Major Articles and Brief Reports, Viruses, crystallographic analysis, human monoclonal antibody, MERS-CoV, neutralizing antibody repertoires, Epitope, Monoclonal antibody, medicine.drug_class, medicine, Epitope mapping, Respiratory infection, Biology, Neutralizing antibody, biology.protein, Antibody, Middle East respiratory syndrome coronavirus, medicine.disease_cause, Neutralization, Virology
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