publication . Article . 2018

Receptor Usage of a Novel Bat Lineage C Betacoronavirus Reveals Evolution of Middle East Respiratory Syndrome-Related Coronavirus Spike Proteins for Human Dipeptidyl Peptidase 4 Binding

Susanna K. P. Lau; Libiao Zhang; Hayes K.H. Luk; Lifeng Xiong; Xingwen Peng; Kenneth S. M. Li; Xiangyang He; Pyrear S.H. Zhao; Rachel Y. Y. Fan; Antonio C. P. Wong; ...
Open Access English
  • Published: 16 Jan 2018 Journal: The Journal of Infectious Diseases, volume 218, issue 2, pages 197-207 (issn: 0022-1899, eissn: 1537-6613, Copyright policy)
  • Publisher: Oxford University Press
Abstract
The discovery of Hp-BatCoV HKU25 bridges the evolutionary gap between MERS-CoV and existing bat viruses, and suggests that bat viruses may have evolved to generate MERS-CoV through modulation of the spike protein for binding to hDPP4.
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Subjects
Medical Subject Headings: virusesrespiratory tract diseasesvirus diseasesbiochemical phenomena, metabolism, and nutritionanimal structures
free text keywords: Major Articles and Brief Reports, Viruses, dipeptidyl peptidase 4, Hypsugo bat, Middle East Respiratory Syndrome coronavirus, spike glycoprotein, Immunology and Allergy, Infectious Diseases, Phylogeny, Evolution, Coronavirus, Virus Internalization, Sequence Analysis, corona viruses, virus-host, Molecular, biotic associations, Humans, pathogen-host, Chiroptera, CETAF-taskforce, biotic interaction, Betacoronavirus, DNA, HEK293 Cells, Dipeptidyl Peptidase 4, Protein Binding, Spike Glycoprotein, Coronaviridae, covid, Virus, covid-19, pathogens, Viridae, Receptors, biotic relations, Animals, Middle East respiratory syndrome, medicine.disease, medicine, Binding domain, Genome, Middle East respiratory syndrome coronavirus, medicine.disease_cause, Betacoronavirus, biology.organism_classification, biology, Dipeptidyl peptidase-4, Phylogenetic tree, Genetics, Coronavirus
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