publication . Article . 2014

Respiratory Syncytial Virus and Other Respiratory Viral Infections in Older Adults With Moderate to Severe Influenza-like Illness

Ann R. Falsey; Janet E. McElhaney; Jiri Beran; Gerrit A van Essen; Xavier Duval; Meral Esen; Florence Galtier; Pierre Gervais; Shinn-Jang Hwang; Peter G. Kremsner; ...
Open Access English
  • Published: 29 Jan 2014
  • Publisher: HAL CCSD
  • Country: France
International audience; Background. Few studies have prospectively assessed viral etiologies of acute respiratory infections in community-based elderly individuals. We assessed viral respiratory pathogens in individuals ≥65 years with influenza-like illness (ILI).Methods. Multiplex reverse-transcriptase polymerase chain reaction identified viral pathogens in nasal/throat swabs from 556 episodes of moderate-to-severe ILI, defined as ILI with pneumonia, hospitalization, or maximum daily influenza symptom severity score (ISS) >2. Cases were selected from a randomized trial of an adjuvanted vs nonadjuvanted influenza vaccine conducted in elderly adults from 15 count...
Persistent Identifiers
Medical Subject Headings: virus diseasesrespiratory tract diseasesviruses
free text keywords: respiratory infection, elderly, respiratory syncytial virus, influenza, epidemiology, prevalence, polymerase chain reaction, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Major Articles and Brief Reports, Viruses, Immunology and Allergy, Infectious Diseases, Influenza vaccine, Respiratory infection, Rhinovirus, medicine.disease_cause, medicine, Internal medicine, medicine.medical_specialty, Respiratory tract infections, Coronavirus, Human metapneumovirus, biology.organism_classification, biology, Vaccination, Immunology, business.industry, business, Influenza-like illness
Funded by
  • Funder: Canadian Institutes of Health Research (CIHR)
22 references, page 1 of 2

1. Larbi A, Franceschi C, Mazzatti D, Solana R, Wikby A, Pawelec G. Aging of the immune system as a prognostic factor for human longevity. Physiology (Bethesda) 2008; 23:64-74.

2. Matsuno O, Kataoka H, Takenaka R, et al. Influence of age on symptoms and laboratory findings at presentation in patients with influenza-associated pneumonia. Arch Gerontol Geriatr 2009; 49:322-5.

3. Govaert TM, Dinant GJ, Aretz K, Knottnerus JA. The predictive value of influenza symptomatology in elderly people. Fam Pract 1998; 15:16-22. [OpenAIRE]

4. She RC, Polage CR, Caram LB, et al. Performance of diagnostic tests to detect respiratory viruses in older adults. Diagn Microbiol Infect Dis 2010; 67:246-50. [OpenAIRE]

5. Talbot HK, Falsey AR. The diagnosis of viral respiratory disease in older adults. Clin Infect Dis 2010; 50:747-51. [OpenAIRE]

6. Ruuskanen O, Lahti E, Jennings LC, Murdoch DR. Viral pneumonia. Lancet 2011; 377:1264-75.

7. Jartti L, Langen H, Söderlund-Venermo M, Vuorinen T, Ruuskanen O, Jartti T. New respiratory viruses and the elderly. Open Respir Med J 2011; 5:61-9.

8. Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE. Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med 2005; 352:1749-59.

9. Falsey AR, Walsh EE. Respiratory syncytial virus infection in adults. Clin Microbiol Rev 2000; 13:371-84.

10. Nicholson KG, Kent J, Hammersley V, Cancio E. Acute viral infections of upper respiratory tract in elderly people living in the community: comparative, prospective, population based study of disease burden. BMJ 1997; 315:1060-4.

11. McElhaney J, Beran J, Devaster J-M, et al. AS03-adjuvanted versus nonadjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial. Lancet Infect Dis 2013; 13:485-96.

12. Osborne RH, Norquist JM, Elsworth GR, et al. Development and validation of the Influenza Intensity and Impact Questionnaire (FluiiQTM). Value Health 2011; 14:687-99.

13. Vesikari T, Beran J, Durviaux S, et al. Use of real-time polymerase chain reaction (rtPCR) as a diagnostic tool for influenza infection in a vaccine efficacy trial. J Clin Virol 2012; 53:22-8.

14. Mahony J, Chong S, Merante F, et al. Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assay. J Clin Microbiol 2007; 45:2965-70.

15. Merante F, Yaghoubian S, Janeczko R. Principles of the xTAG respiratory viral panel assay (RVP Assay). J Clin Virol 2007; 40(Suppl 1): S31-5.

22 references, page 1 of 2
Any information missing or wrong?Report an Issue