publication . Article . 2013

Investigation of Anti–Middle East Respiratory Syndrome Antibodies in Blood Donors and Slaughterhouse Workers in Jeddah and Makkah, Saudi Arabia, Fall 2012

Asad S. Aburizaiza; Frank M. Mattes; Esam I. Azhar; Ahmed M. Hassan; Ziad A. Memish; Doreen Muth; Benjamin Meyer; Erik Lattwein; Marcel A. Müller; Christian Drosten;
Open Access English
  • Published: 11 Nov 2013 Journal: The Journal of Infectious Diseases, volume 209, issue 2, pages 243-246 (issn: 0022-1899, eissn: 1537-6613, Copyright policy)
  • Publisher: Oxford University Press
Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel, potentially zoonotic human coronavirus (HCoV). We investigated MERS-CoV antibodies using a staged approach involving an immunofluorescence assay (IFA), a differential recombinant IFA, and a plaque-reduction serum neutralization assay. In 130 blood donors sampled during 2012 in Jeddah and 226 slaughterhouse workers sampled in October 2012 in Jeddah and Makkah, Saudi Arabia, 8 reactive sera were seen in IFA but were resolved to be specific for established HCoVs by discriminative testing. There is no evidence that MERS-CoV circulated widely in the study region in fall 2012, matching an app...
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Medical Subject Headings: virus diseasesparasitic diseasesviruses
free text keywords: Major Articles and Brief Reports, Viruses, Editor's Choice, MERS-Coronavirus, serology, population immunity, Immunology and Allergy, Infectious Diseases, Neutralization test, Antibody, biology.protein, biology, Middle East respiratory syndrome coronavirus, medicine.disease_cause, medicine, Serology, Seroepidemiologic Studies, Virology, Middle East respiratory syndrome, medicine.disease, Hajj, business.industry, business, Coronavirus

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