publication . Article . Other literature type . 2011

The Ebola Virus Glycoprotein and HIV-1 Vpu Employ Different Strategies to Counteract the Antiviral Factor Tetherin

Annika Kühl; Carina Banning; Andrea Marzi; Jörg Votteler; Imke Steffen; Stephanie Bertram; Ilona Glowacka; Andreas Konrad; Michael Stürzl; Ju-Tao Guo; ...
Open Access
  • Published: 01 Nov 2011 Journal: The Journal of Infectious Diseases, volume 204, issue suppl_3, pages S850-S860 (issn: 0022-1899, eissn: 1537-6613, Copyright policy)
  • Publisher: Oxford University Press (OUP)
Abstract
The interferon-α (IFNα)–inducible cellular protein tetherin is a novel human immunodeficiency virus (HIV) restriction factor, which inhibits the release of progeny virions from infected cells [1, 2]. The antiviral action of tetherin is counteracted by the HIV-1 accessory viral protein U (Vpu), which is required for efficient release of HIV-1 from tetherin-expressing cells [2]. Thus, tetherin might constitute a potent barrier against Vpu-deficient HIV-1, and the molecular mechanism underlying tetherin inhibition by Vpu might be a target for therapeutic inhibition [3]. Ebola virus (EBOV) and Marburg virus (MARV) are enveloped, negative-stranded RNA viruses that co...
Persistent Identifiers
Subjects
Medical Subject Headings: viruses
free text keywords: Viral Biology, Viral protein, medicine.disease_cause, medicine, Virology, Viral membrane, VP40, Tetherin, Viral budding, Viral envelope, Ebola virus, Biology, Filoviridae, biology.organism_classification
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