publication . Article . Other literature type . 2011

Comparative Analysis of Ebola Virus Glycoprotein Interactions With Human and Bat Cells

Annika Kühl; Markus Hoffmann; Marcel A. Müller; Vincent J. Munster; Kerstin Gnirß; Miriam Kiene; Theodros Solomon Tsegaye; Georg M. N. Behrens; Georg Herrler; Heinz Feldmann; ...
Open Access
  • Published: 01 Nov 2011 Journal: The Journal of Infectious Diseases, volume 204, issue suppl_3, pages S840-S849 (issn: 0022-1899, eissn: 1537-6613, Copyright policy)
  • Publisher: Oxford University Press (OUP)
Infection with Ebola virus (EBOV) causes hemorrhagic fever in humans with high case-fatality rates. The EBOV-glycoprotein (EBOV-GP) facilitates viral entry and promotes viral release from human cells. African fruit bats are believed not to develop disease upon EBOV infection and have been proposed as a natural reservoir of EBOV. We compared EBOV-GP interactions with human cells and cells from African fruit bats. We found that susceptibility to EBOV-GP-dependent infection was not limited to bat cells from potential reservoir species, and we observed that GP displayed similar biological properties in human and bat cells. The only exception was GP localization, whi...
Persistent Identifiers
free text keywords: Viral Biology, Immunology and Allergy, Infectious Diseases, Virology, Ebolavirus, medicine.disease_cause, medicine, Tropism, Disease reservoir, Viral replication, Ebola virus, Natural reservoir, Viral entry, Glycoprotein, chemistry.chemical_classification, chemistry, Biology
Funded by
European Management Platform for Emerging and Re-emerging Infectious disease Entities
  • Funder: European Commission (EC)
  • Project Code: 223498
  • Funding stream: FP7 | SP1 | HEALTH
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