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Publication . Article . Other literature type . 2021

Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources

Samuele Bovo; Giuseppina Schiavo; Anisa Ribani; Valerio Joe Utzeri; Valeria Taurisano; Mohamad Ballan; María Muñoz; +25 Authors
Open Access
English
Published: 01 Dec 2021 Journal: Scientific Reports, volume 11, issue 1 (eissn: 2045-2322, Copyright policy )
Abstract

AbstractCoronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a “One Health” perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants were identified in the four candidate genes: 26% of them were not previously described; 29 variants affected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a first step towards a “One Health” perspective that should consider conservation programs of pig genetic resources with twofold objectives: (i) genetic resources could be reservoirs of host gene variability useful to design selection programs to increase resistance to coronaviruses; (ii) the described variability in genes involved in coronavirus infections across many different pig populations might be part of a risk assessment including pig genetic resources.

Subjects by Vocabulary

Microsoft Academic Graph classification: Candidate gene Context (language use) One Health Genetic variation Biology Gene Whole genome sequencing Genetics Host (biology) Population education.field_of_study education

Subjects

Medicine, R, Science, Q, Angiotensin-Converting Enzyme 2, Animal, Breeding, CD13 Antigen, Coronavirus Infection, Dipeptidyl Peptidase 4, Gene Frequency, Genetics, Population, High-Throughput Nucleotide Sequencing, Human, INDEL Mutation, One Health, Polymorphism, Single Nucleotide, Receptors, Viru, Serine Endopeptidase, Sus scrofa, Swine, Whole Genome Sequencing, Genetic Variation, pig ; local breed ; whole genome sequencing ; coronavirus, MESH: Angiotensin-Converting Enzyme 2, MESH: Animals, MESH: Genetics, Population, MESH: High-Throughput Nucleotide Sequencing, MESH: Humans, MESH: INDEL Mutation, MESH: One Health, MESH: Polymorphism, Single Nucleotide, MESH: Receptors, Virus, MESH: Serine Endopeptidases, MESH: Sus scrofa, MESH: Swine, MESH: Whole Genome Sequencing, MESH: Breeding, MESH: CD13 Antigens, MESH: Coronavirus Infections, MESH: Dipeptidyl Peptidase 4, MESH: Gene Frequency, MESH: Genetic Variation, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, Article, Infectious diseases, Data mining, Next-generation sequencing, Agricultural genetics, Animal breeding, Genetic markers, Genomics, Population genetics, 619, Multidisciplinary, Angiotensin-Converting Enzyme 2; Animals; Breeding; CD13 Antigens; Coronavirus Infections; Dipeptidyl Peptidase 4; Gene Frequency; Genetics, Population; High-Throughput Nucleotide Sequencing; Humans; INDEL Mutation; One Health; Polymorphism, Single Nucleotide; Receptors, Virus; Serine Endopeptidases; Sus scrofa; Swine; Whole Genome Sequencing; Genetic Variation, Animals, CD13 Antigens, Coronavirus Infections, Genetics, Population, Humans, Polymorphism, Single Nucleotide, Receptors, Virus, Serine Endopeptidases

Funded by
EC| TREASURE
Project
TREASURE
DIVERSITY OF LOCAL PIG BREEDS AND PRODUCTION SYSTEMS FOR HIGH QUALITY TRADITIONAL PRODUCTS AND SUSTAINABLE PORK CHAINS
  • Funder: European Commission (EC)
  • Project Code: 634476
  • Funding stream: H2020 | RIA
Validated by funder
,
EC| TREASURE
Project
TREASURE
DIVERSITY OF LOCAL PIG BREEDS AND PRODUCTION SYSTEMS FOR HIGH QUALITY TRADITIONAL PRODUCTS AND SUSTAINABLE PORK CHAINS
  • Funder: European Commission (EC)
  • Project Code: 634476
  • Funding stream: H2020 | RIA
Validated by funder
Related to Research communities
COVID-19
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