publication . Article . 2005

Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase

Yi Ru Gan; He Huang; Yong Dong Huang; Chun Ming Rao; Yang Zhao; Jin Sheng Liu; Lei Wu; Dong-Qing Wei;
Open Access English
  • Published: 20 Oct 2005 Journal: Peptides, volume 27, issue 4, pages 622-625 (issn: 0196-9781, eissn: 1873-5169, Copyright policy)
  • Publisher: Elsevier Inc.
Abstract
Abstract The outbreak of SARS, a life-threatening disease, has spread over many countries around the world. So far there is no effective drug for the treatment of SARS. Stimulated by the binding mechanism of SARS-CoV M pro with the octapeptide AVLQSGFR reported recently as well as the “Chou's distorted key” theory, we synthesized the octapeptide AVLQSGFR for conducting various biochemical experiments to investigate the antiviral potential of the octapeptide against SARS coronavirus (BJ-01). The results demonstrate that, compared with other compounds reported so far, AVLQSGFR is the most active in inhibiting replication of the SARS coronavirus, and that no detect...
Subjects
Medical Subject Headings: skin and connective tissue diseasesfungibody regions
free text keywords: Article, SARS, Coronavirus proteinase, Octapeptide AVLQSGFR, “Chou's distorted key” theory, Biochemistry, Physiology, Endocrinology, Cellular and Molecular Neuroscience, Peptide sequence, Virology, Biology, Lung disease, Enzyme, chemistry.chemical_classification, chemistry, Vero cell, Severe acute respiratory syndrome coronavirus
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