publication . Article . 2004

Potential targets for anti-SARS drugs in the structural proteins from SARS related coronavirus

Guang Wu; Shaomin Yan;
Open Access English
  • Published: 13 Apr 2004 Journal: Peptides, volume 25, issue 6, pages 901-908 (issn: 0196-9781, eissn: 1873-5169, Copyright policy)
  • Publisher: Elsevier Inc.
This is a further study on the severe acute respiratory syndrome (SARS) using the probabilistic models. The purpose was to define the potential targets for anti-SARS drugs in the structural proteins from human SARS related coronavirus (SARS-CoV) while knowing little about the functional sites and possible mutations in these proteins. From a probabilistic viewpoint, we can theoretically select the amino acid pairs as potential candidates for anti-SARS drugs. These candidates have a greater chance of colliding with anti-SARS drugs, are more likely to link with the protein functions and are less vulnerable to mutations.
Medical Subject Headings: fungiskin and connective tissue diseasesbody regions
free text keywords: Article, Amino acid pairs, Coronavirus, Drug targets, SARS, Biochemistry, Physiology, Endocrinology, Cellular and Molecular Neuroscience, Drug, media_common.quotation_subject, media_common, Virology, Sequence analysis, Biology, Amino acid, chemistry.chemical_classification, chemistry, Coronavirus, medicine.disease_cause, medicine, Severe acute respiratory syndrome-related coronavirus
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