publication . Article . 2021

Corticosteroid Therapy Is Associated With Improved Outcome in Critically Ill Patients With COVID-19 With Hyperinflammatory Phenotype

Hui Chen; Jianfeng Xie; Nan Su; Jun Wang; Qin Sun; Shusheng Li; Jun Jin; Jing Zhou; Min Mo; Yao Wei; ...
Open Access
  • Published: 01 May 2021 Journal: Chest, volume 159, pages 1,793-1,802 (issn: 0012-3692, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Background Corticosteroid therapy is commonly used in patients with coronavirus disease 2019 (COVID-19), while its impact on outcomes and which patients could benefit from corticosteroid therapy are uncertain. Research question Whether clinical phenotypes of COVID-19 were associated with differential response to corticosteroid therapy. Study design and methods Critically ill patients with COVID-19 from Tongji hospital between Jan 2020 and Feb 2020 were included, and the main exposure of interest was the administration of intravenous corticosteroids. The primary outcome was 28-day mortality. Marginal structural modeling was used to account for baseline and time-d...
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free text keywords: Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, Pulmonary and Respiratory Medicine, Internal medicine, medicine.medical_specialty, medicine, Phenotype, business.industry, business, Coronavirus disease 2019 (COVID-19), Neutrophil to lymphocyte ratio, Corticosteroid, medicine.drug_class, Middle East respiratory syndrome, medicine.disease, Fraction of inspired oxygen, Confounding, ARDS
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