publication . Article . Other literature type . 2017

The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands

Hilton, Hugo G.; McMurtrey, Curtis P.; Han, Alex S.; Djaoud, Zakia; Guethlein, Lisbeth A.; Blokhuis, Jeroen H.; Pugh, Jason L.; Goyos, Ana; Horowitz, Amir; Buchli, Rico; ...
Open Access English
  • Published: 01 May 2017 Journal: Cell Reports, volume 19, issue 7, pages 1,394-1,405 (issn: 2211-1247, Copyright policy)
  • Publisher: Elsevier
Abstract
HLA-B∗46:01 was formed by an intergenic mini-conversion, between HLA-B∗15:01 and HLA-C∗01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-conversion was introduction of the C1 epitope into HLA-B∗46:01, making it an exceptional HLA-B allotype that is recognized by the C1-specific natural killer (NK) cell receptor KIR2DL3. High-resolution mass spectrometry showed that HLA-B∗46:01 has a low-diversity peptidome that is distinct from those of its parents. A minority (21%) of HLA-B∗46:01 peptides, with common C-terminal characteristics, form ligands for KIR2DL3. The...
Subjects
free text keywords: HLA class I, KIR, antigen presentation, genetic polymorphism, host-pathogen interactions, modern human migration, peptidome, mass spectrometry, Article, ANTIGEN PRESENTATION, GENETIC POLYMORPHISM, HLA CLASS I, HOST-PATHOGEN INTERACTIONS, KIR, MASS SPECTROMETRY, MODERN HUMAN MIGRATION, PEPTIDOME, Salud Ocupacional, Ciencias de la Salud, CIENCIAS MÉDICAS Y DE LA SALUD, General Biochemistry, Genetics and Molecular Biology, lcsh:Biology (General), lcsh:QH301-705.5, Mycobacterium leprae, biology.organism_classification, biology, Genetics, HLA-B Antigens, Epitope, HLA-B, Intergenic region, Human leukocyte antigen, Antigen, Allotype
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