publication . Article . Conference object . 2003

In vivo animal model of an innate immune response to a coronavirus: the production of interferon alpha induced by porcine transmissible gastroenteritis virus (TGEV)

Charley, Bernard;
  • Published: 26 Jun 2003
  • Publisher: HAL CCSD
  • Country: France
National audience; Interferons are a family of molecules produced in response to a viral aggression. The author focuses here on alpha interferon, describing its biological properties (antiviral, immunomodulator, antitumoral and responsible for side effects such as fever), as well as its induction and production mechanisms. He used an experimental infection model in piglets with the transmissible gastroenteritis virus (TGEV) to describe the mechanism of alpha interferon production, the exact nature of the producing cells, which are neither T lymphocytes nor B lymphocytes, but which express the class II major histocompatibility complex. Cells with the same propert...
free text keywords: INTERFERON, CORONAVIRUS, TGEV, SRAS, SARS, PIG, PORC, VACCINATION, CELLULES NIP, NIP CELLS, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
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