publication . Article . 2021

Early laboratory diagnosis of COVID-19 by antigen detection in blood samples of the SARS-COV-2 nucleocapsid protein

Thudium, Rebekka F; Stoico, Malene P; Høgdall, Estrid; Høgh, Julie; Krarup, Henrik B; Larsen, Margit A H; Madsen, Poul H; Nielsen, Susanne D; Ostrowski, Sisse R; Palombini, Amanda; ...
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  • Published: 14 Jul 2021
  • Country: Denmark
Abstract
<p>The purpose of this study was to characterize the diagnostic performance of a newly developed enzyme-linked immunosorbent assay (ELISA) for detection of SARS-CoV-2 nucleocapsid protein (NP) in blood. Blood samples were collected during hospitalization of 165 inpatients with PCR-confirmed SARS-CoV-2 infection, and from 505 outpatients with relevant symptoms of COVID-19 simultaneously with PCR-testing. For the 143 inpatients who had their first blood sample collected within 2 weeks after PCR-confirmed infection, the diagnostic sensitivity of the ELISA was 91.6%. The mean NP concentration of the 131 ELISA-positive blood samples was 1,734 pg/ml (range: [10-3,840]...
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Article . 2021
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