project . 2022 - 2024 . Not started

HumBrain

Computational modelling of the human brain lipidome
Open Access mandate for Publications and Research DataOpen Access mandate for ... European Commission
  • Funder: European CommissionProject code: 101023783 Call for proposal: H2020-MSCA-IF-2020
  • Funded under: H2020 | MSCA-IF-EF-RI Overall Budget: 207,312 EURFunder Contribution: 207,312 EUR
  • Status: Not started
  • Start Date
    01 Mar 2022
    End Date
    29 Feb 2024
  • Detailed project information (CORDIS)
Description
The blood-brain barrier (BBB) is a complex interface that separates the central nervous system (CNS) from the circulatory system and serves to maintain brain homeostasis. There are native P-glycoprotein (P-gp) transporters embedded in the BBB endothelial cell membranes, which play a fundamental role in effluxing out xenobiotics. Such protections come at a steep price, since the BBB is a key roadblock in the delivery of treatments for CNS disorder, including brain tumors and Alzheimer’s, while the P-glycoprotein transporter reduces the effectiveness of chemotherapeutics and is responsible for the development of multidrug resistance (MDR). The HumBrain project wil...
Partners
Description
The blood-brain barrier (BBB) is a complex interface that separates the central nervous system (CNS) from the circulatory system and serves to maintain brain homeostasis. There are native P-glycoprotein (P-gp) transporters embedded in the BBB endothelial cell membranes, which play a fundamental role in effluxing out xenobiotics. Such protections come at a steep price, since the BBB is a key roadblock in the delivery of treatments for CNS disorder, including brain tumors and Alzheimer’s, while the P-glycoprotein transporter reduces the effectiveness of chemotherapeutics and is responsible for the development of multidrug resistance (MDR). The HumBrain project wil...
Partners
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