project . 2015 - 2017 . Closed

Leucophyl

Total Synthesis of Leucophyllidine
Open Access mandate for Publications and Research DataOpen Access mandate for ... European Commission
  • Funder: European CommissionProject code: 655527 Call for proposal: H2020-MSCA-IF-2014
  • Funded under: H2020 | MSCA-IF-EF-ST Overall Budget: 185,076 EURFunder Contribution: 185,076 EUR
  • Status: Closed
  • Start Date
    15 Dec 2015
    End Date
    14 Dec 2017
  • Detailed project information (CORDIS)
Description
In the frame of this research program, carried out at the Institute of Molecular Sciences (ISM) at the University of Bordeaux (UB), we propose a strategy directed towards the first total synthesis of leucophyllidine, a cytotoxic alkaloid recently isolated from L. griffithii. From the retrosynthetic analysis of the target, two fragments where identified that will be prepared then connected in the last stage of the synthesis, following a biomimetic approach. The “North-fragment” will be synthesized relying on a coupling between a key-aldehyde moiety and tryptamine through a Pictet-Spengler reaction/lactamization cascade. The “South-fragment” will be elaborated usi...
Description
In the frame of this research program, carried out at the Institute of Molecular Sciences (ISM) at the University of Bordeaux (UB), we propose a strategy directed towards the first total synthesis of leucophyllidine, a cytotoxic alkaloid recently isolated from L. griffithii. From the retrosynthetic analysis of the target, two fragments where identified that will be prepared then connected in the last stage of the synthesis, following a biomimetic approach. The “North-fragment” will be synthesized relying on a coupling between a key-aldehyde moiety and tryptamine through a Pictet-Spengler reaction/lactamization cascade. The “South-fragment” will be elaborated usi...
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