project . 2018 - 2023 . On going

ENVISION

Novel mechanisms of early defense against virus infections
Open Access mandate for Publications and Research DataOpen Access mandate for ... European Commission
  • Funder: European CommissionProject code: 786602 Call for proposal: ERC-2017-ADG
  • Funded under: H2020 | ERC | ERC-ADG Overall Budget: 2,480,340 EURFunder Contribution: 2,480,340 EUR
  • Status: On going
  • Start Date
    01 Dec 2018
    End Date
    30 Nov 2023
  • Detailed project information (CORDIS)
Description
Virus-induced type I interferons (IFN) have classically been considered to constitute the first line of defense against virus infections However, recent work by us and others has identified early antiviral actions that occur independently of inducible type I and III IFN expression and sometimes even prior to IFN action (e.g. Iversen,...., Paludan. Nature Immunology, 2016; Paludan. Trends in Immunology, 2016). These discoveries challenge the current thinking in the field that IFNs constitute the first line of defense. Hence, there is an urgent need for more detailed understanding of the immediate antiviral defense mechanisms. Most importantly, we remain to identi...
Partners
Description
Virus-induced type I interferons (IFN) have classically been considered to constitute the first line of defense against virus infections However, recent work by us and others has identified early antiviral actions that occur independently of inducible type I and III IFN expression and sometimes even prior to IFN action (e.g. Iversen,...., Paludan. Nature Immunology, 2016; Paludan. Trends in Immunology, 2016). These discoveries challenge the current thinking in the field that IFNs constitute the first line of defense. Hence, there is an urgent need for more detailed understanding of the immediate antiviral defense mechanisms. Most importantly, we remain to identi...
Partners
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