Powered by OpenAIRE graph
Found an issue? Give us feedback

Fight-nCoV

FIGHTING-OFF CORONAVIRUS (SARS-CoV-2) WITH BROAD-SPECTRUM ANTIVIRALS: ESTABLISHING ANIMAL VIRAL CHALLENGE MODEL
Funder: European CommissionProject code: 101003555 Call for proposal: H2020-SC1-PHE-CORONAVIRUS-2020
Funded under: H2020 | RIA Overall Budget: 2,807,030 EURFunder Contribution: 2,807,030 EUR
Open Access mandate
Research data: No

Fight-nCoV

Description

Project coordinator: Professor Anna-Lena Spetz, MD, PhD, Stockholm University, Sweden Objectives of proposal: Our consortium “Fight-nCoV” will accelerate preclinical development of new broad-spectrum antivirals for inhalation, building on breath-taking ongoing research. We will determine and characterize the antiviral activity and safety of three viral entry inhibitors (oligonucleotide, Macro-I, tweezer) against SARS-CoV-2 in vitro and in vivo. To enable this, we will build capacity for evaluation of antiviral efficacy against SARS-CoV-2 in vitro using viral pseudotypes and wild-type SARS-CoV-2 as well as in vivo in non-human primates. Safety studies will be performed according to OECD GLP guidelines. Expected results: We will establish a SARS-CoV-2 spike pseudotype system allowing a standardized high throughput evaluation of the antiviral activity of candidate drugs. We will have determined the antiviral efficacy of three novel broad-spectrum viral entry inhibitors: oligonucleotide, macromolecular polymers, and molecular tweezers. We will also build capacity for innovation and preclinical evaluation of our broad-spectrum antivirals and vaccines against SARS-CoV-2 by establishing a macaque challenge model. “Fight-nCoV” will provide efficacy data of our drug candidates given intranasally in non-human primates challenged with SARS-CoV-2, enable an early and valuable outcome for stakeholders and the civil society. Timeline of proposal: Ongoing-30 months Key partners: Roger Le Grand, Director animal facility, CEA, France; Urban Höglund, CEO Adlego Biomedical, Sweden; Jan Münch, Professor in Molecular Virology, UULM, Germany; Alexander Zelikin, Associate Professor, formulation expert, AU, Denmark; and Thomas Schrader, Professor of Chemistry, UDE, Germany.

Data Management Plans
Powered by OpenAIRE graph
Found an issue? Give us feedback

Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.

All Research products
arrow_drop_down
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=corda__h2020::bf640d6d04a4915e40d01c458a0f6fda&type=result"></script>');
-->
</script>
For further information contact us at helpdesk@openaire.eu

No option selected
arrow_drop_down