research product . Other ORP type . 2004

The aetiology of SARS: Koch's postulates fulfilled

Osterhaus, Albert; Fouchier, Ron; Kuiken, Thijs;
Open Access English
  • Published: 29 Jul 2004
  • Country: Netherlands
Abstract
Proof that a newly identified coronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV) is the primary cause of severe acute respiratory syndrome (SARS) came from a series of studies on experimentally infected cynomolgus macaques (Macaca, fascicularis). SARS-CoV-infected macaques developed a disease comparable to SARS in humans; the virus was re-isolated from these animals and they developed SARS-CoV-specific antibodies. This completed the fulfilment of Koch's postulates, as modified by Rivers for viral diseases, for SARS-CoV as the aetiological agent of SARS. Besides the macaque model, a ferret and a cat model for SARS-CoV were also developed. These...
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Medical Subject Headings: skin and connective tissue diseasesfungibody regionsvirus diseasesviruses
free text keywords: Aetiology, Koch's postulates, SARS, SARS-CoV
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