research product . Other ORP type . 2021

How does SARS-CoV-2 targets the elderly patients?: A review on potential mechanisms increasing disease severity

Smorenberg, Annemieke; Peters, E.J. (Edgar JG); Daele, Paul; Nossent, E.J. (Esther J); Muller, Majon;
Open Access English
  • Published: 01 Jan 2021
  • Country: Netherlands
Abstract
IMPORTANCE: Among COVID-19 cases, especially the (frail) elderly show a high number of severe infections, hospital admissions, complications, and death. The highest mortality is found between 80 and 89 years old. Why do these patients have a higher risk of severe COVID-19? In this narrative review we address potential mechanisms regarding viral transmission, physical reserve and the immune system, increasing the severity of this infection in elderly patients. OBSERVATIONS: First, the spread of COVID-19 may be enhanced in elderly patients. Viral shedding may be increased, and early identification may be complicated due to atypical disease presentation and limited...
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free text keywords: COVID19, elderly patients, geriatric care, immunology, Internal Medicine
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