research product . 2020

Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study

Cummings, Matthew J et al.;
Open Access English
  • Published: 20 Apr 2020
Background: Nearly 30,000 patients with coronavirus disease-2019 (COVID-19) have been hospitalized in New York City as of April 14th, 2020. Data on the epidemiology, clinical course, and outcomes of critically ill patients with COVID-19 in this setting are needed. Methods: We prospectively collected clinical, biomarker, and treatment data on critically ill adults with laboratory-confirmed-COVID-19 admitted to two hospitals in northern Manhattan between March 2nd and April 1st, 2020. The primary outcome was in-hospital mortality. Secondary outcomes included frequency and duration of invasive mechanical ventilation, frequency of vasopressor use and renal-replaceme...
Persistent Identifiers
free text keywords: COVID-19, Coronavirus, United States, Environmental Biomarkers, Mortality, Respiration, Artificial, Cohort Studies
Funded by
NIH| Clinical and Translational Science Award
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5UL1TR001873-03
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29 references, page 1 of 2

1 Centers for Disease Control and Prevention. Coronavirus disease 2019 (COVID-19): cases in the U.S. 2019-ncov/cases-updates/cases-in-us.html (accessed April 28, 2020).

2 New York State Department of Health. COVID-19 tracker. NYSDOHCOVID-19Tracker-Map?%3Aembed=yes&%3Atoolbar=no &%3Atabs=n (accessed April 28, 2020).

3 Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020; published online Feb 24. DOI:10.1001/jama.2020.2648. [OpenAIRE]

4 Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020; 382: 1708-20.

5 Grasselli G, Pesenti A, Cecconi M. Critical care utilization for the COVID-19 outbreak in Lombardy, Italy: early experience and forecast during an emergency response. JAMA 2020; published online March 13. DOI:10.1001/jama.2020.4031. [OpenAIRE]

6 Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a singlecentered, retrospective, observational study. Lancet Respir Med 2020; published online Feb 24. S2213-2600(20)30079-5.

7 Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395: 1054-62.

8 Grasselli G, Zangrillo A, Zanella A, et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy. JAMA 2020; published online April 6. DOI:10.1001/jama.2020.5394.

9 Arentz M, Yim E, Klaf L, et al. Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington State. JAMA 2020; published online March 19. DOI:10.1001/jama.2020.4326.

10 Bhatraju PK, Ghassemieh BJ, Nichols M, et al. COVID-19 in critically ill patients in the Seattle region-case series. N Engl J Med 2020; published online March 30. DOI:10.1056/ NEJMoa2004500.

11 WHO. R&D Blueprint: COVID-19 therapeutic trial synopsis. Feb 18, 2020. synopsis_Final_18022020.pdf (accessed April 11, 2020).

12 Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 2020; 395: 1033-34.

13 Helms J, Tacquard C, Severac F, et al. High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Med 2020; published online May 4. DOI:10.1007/s00134-020-06062-x.

14 Kelly CA, Upex A, Bateman DN. Comparison of consciousness level assessment in the poisoned patient using the alert/verbal/painful/ unresponsive scale and the Glasgow Coma Scale. Ann Emerg Med 2004; 44: 108-13. [OpenAIRE]

15 CDC COVID-19 Response Team. Severe outcomes among patients with coronavirus disease 2019 (COVID-19)-United States, February 12-March 16, 2020. MMWR Morb Mortal Wkly Rep 2020; 69: 343-46.

29 references, page 1 of 2
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