research product . 2020

Corticosteroids for patients with acute respiratory distress syndrome: a systematic review and meta-analysis of randomized trials

Mammen MJ. Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA;
Open Access
  • Published: 18 Mar 2020
Introduction: Acute respiratory distress syndrome (ARDS) is a rapidly progressing inflammatory lung disease with a high mortality rate without specific pharmacological therapy. Objective: We conducted a systematic review and meta-analysis on corticosteroid use in ARDS. Methods: A search of four medical literature databases was conducted. We retained randomized trials (RCTs) of corticosteroids in hospitalized adults with ARDS in a search up to February, 2020. Two reviewers identified eligible studies, independently extracted data, and assessed risk of bias. Authors assessed the certainty of the evidence using the Grading of Recommendations, Assessment, Developmen...
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